Detecção do HPV na cavidade oral: uma revisão sistemática
Palavras-chave:
HPV oral, prevalência, limites, áreas de oportunidadeResumo
Introdução. Os testes de detecção do HPV na cavidade oral têm ganhado vital importância como um método alternativo frente às técnicas tradicionais desde o final do século passado; no entanto, é poco descrita na literatura a prevalência do HPV oral, e os limites e áreas de oportunidade sobre sua aplicação.
Objetivos. Rever a informação atualizada sobre os testes de HPV oral, a prevalência do HPV, e os limites e áreas de oportunidade sobre a aplicação dos testes de detecção de HPV oral.
Metodologia. Realizou-se uma análise sistemática na PubMed com artigos publicados entre 1998-2020, indexados em JCR, se seguiram as recomendações da declaração PRISMA e medidas propostas por Holly, Salmon e Saimbert (2016). Os artigos foram selecionados concorde a uma rubrica que continha os critérios de inclusão. A análise dos dados se sintetizou narrativamente e os resultados foram tabelados de forma individual em Excel.
Resultados. Se incluíram 16 artigos, se determinou a prevalência do HPV na cavidade oral num 6,9%, como limites, a falta de literatura e conhecimento do tema, e áreas de oportunidade da criação de novos métodos de detecção de HPV oral.
Conclusões. Os testes de HPV na cavidade oral são uma boa escolha face às provas convencionais, porém é necessária mais informação em relação a sua divulgação, conscientização os pacientes e pessoal de saúde que conheçam o tema e seja aplicado. Deve se trabalhar em criar novos métodos de detecção de HPV oral. Palavras chave. HPV oral, prevalência, limites, áreas de oportunidade.
Referências
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Akbulut, N., & Altan, A. (2018). Early Detection and Multidisciplinary Approach to Oral Cancer Patients. En S. Sundaresan (Ed.), Prevention, Detection and Management of Oral Cancer. IntechOpen. https://doi.org/10.5772/intechopen.81126
Badaracco, G., Venuti, A., Di Lonardo, A., Scambia, G., Mozzetti, S., Panici, P. B. & Marcante, M. L. (1998). Concurrent HPV infection in oral and genital mucosa. Journal of oral pathology & medicine, 27(3), 130-134. https://doi.org/10.1111/j.1600-0714.1998.tb01928.x
Brondani, M. A., Siqueira, A. B., & Alves, C. M. C. (2019). Exploring lay public and dental professional knowledge around HPV transmission via oral sex and oral cancer development. BMC public health, 19(1), 1529. https://doi.org/10.1186/s12889-019-7923-6
Broutian, T. R., He, X., & Gillison, M. L. (2011). Automated high throughput DNA isolation for detection of human papillomavirus in oral rinse samples. Journal of clinical virology, 50(4), 270-275. https://doi.org/10.1016/j.jcv.2010.12.005
Bustamante Ramos, G. M., Martínez Sánchez, A., Tenahua Quitl, I., Jiménez, C. & López Mendoza, Y. (2015). Conocimiento y prácticas de prevención sobre el virus del papiloma humano (VPH) en universitarios de la Sierra Sur, Oaxaca. Anales de la Facultad de Medicina, 76(4), 369-376. UNMSM. Facultad de Medicina. https://doi.org/10.15381/anales.v76i4.11406
Cameron, J. E., Snowhite, I. V., Chaturvedi, A. K., & Hagensee, M. E. (2003). Human papillomavi- rus-specific antibody status in oral fluids modestly reflects serum status in human immunodeficiency virus-positive individuals. Clin. Diagn. Lab. Immunol., 10(3), 431-438. https://doi.org/10.1128/cdli.10.3.431-438.2003
Dang, J., Feng, Q., Eaton, K. D., Jang, H. & Kiviat, N. B. (2015). Detection of HPV in oral rinse samples from OPSCC and non-OPSCC patients. BMC oral health, 15(1), 126. https://doi.org/10.1186/s12903-015-0111-x
Flake, C., Arafa, J., Hall, A., Ence, E., Howard, K. & Kingsley, K. (2012). Screening and detection of human papillomavirus (HPV) high-risk strains HPV16 and HPV18 in saliva samples from subjects under 18 years old in Nevada: a pilot study. BMC oral health, 12(1), 43. https://doi.org/10.1186/1472-6831-12-43
Gillison, M. L., Broutian, T., Pickard, R. K., Tong, Z. Y., Xiao, W., Kahle, L. & Chaturvedi, A. K. (2012). Prevalence of oral HPV infection in the United States, 2009-2010. Jama, 307(7), 693-703. https://doi.org/10.1001%2Fjama.2012.101
Hanna, G. J., Lau, C. J., Mahmood, U., Supplee, J. G., Mogili, A. R., Haddad, R. I., Jänne, P. A. & Paweletz, C. P. (2019). Salivary HPV DNA informs locoregional disease status in advanced HPV-associated oropharyngeal cancer. Oral oncology, 95, 120-126. https://doi.org/10.1016/j.oraloncology.2019.06.019
Holly, C., Salmond, S., & Saimbert, M. (2016). Comprehensive Systematic Review for Advanced Practice Nursing (2a ed.). New York: Springer Publishing Company. https://doi.org/10.1891/9780826131867
Karita, H. C. S., Magaret, A., Huang, M. L., Jerome, K. R., Feng, Q. & Wald, A. (2020). Quantitative oral hpv16 and hpv18 detection in persons attending dental clinics. Sexually Transmitted Diseases, 47(2), 100-104. https://doi.org/10.1097/olq.0000000000001097
Knight, G., & Roberts, B. (2020). Awareness of oral and genital human papillomavirus (HPV) infection in young adolescents prior to gender-neutral vaccination. BMJ Sexual & Reproductive Health. 2020 Apr 2: bmjsrh-2019-200410. https://doi.org/10.1136/bmjsrh-2019-200410
Kreimer, A. R., Campbell, C. M. P., Lin, H. Y., Fulp, W., Papenfuss, M. R., Abrahamsen, M. & Giuliano, A. R. (2013). Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. The Lancet, 382(9895), 877-887. https://doi.org/10.1016/s0140-6736(13)60809-0
Parker, K. H., Kemp, T. J., Pan, Y., Yang, Z., Giuliano, A. R., & Pinto, L. A. (2018). Evaluation of HPV-16 and HPV-18 specific antibody measurements in saliva collected in oral rinses and merocel® sponges. Vaccine, 36(19), 2705-2711. https://doi.org/10.1016/j.vaccine.2018.03.034
Pérez-Quintanilla M, Méndez-Martínez R, Vázquez-Vega S, Espinosa-Romero R, Sotelo-Regil R, Pérez-Montiel MD, et al. (2020) High prevalence of human papillomavirus and European vari- ants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women. PLoS ONE, 15(4), e0227900, 1-14. https://doi.org/10.1371/journal.pone.0227900
Pickard, R. K., Xiao, W., Broutian, T. R., He, X. & Gillison, M. L. (2012). The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sexually transmitted diseases, 39(7), 559-566. https://doi.org/10.1097/olq.0b013e31824f1c65
Sánchez Vargas, L. O., Díaz Hernández, C., & Martinez Martinez, A. (2010). Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices. Infectious agents and cancer, 5(1), 1-6. https://doi.org/10.1186%2F1750-9378-5-25
Sayyah Melli, M., Kazemi Sheshvan, M., Bonyadi, M., Ouladsahebmadarek, E., Dasranj Tabrizi, A., Ghojazadeh, M. & Mostafa-Gharabaghi, P. (2011). Detection of human papillomavirus in the saliva of women with concurrent human papillomavirus related genital lesions. Saudi medical journal, 32(2), 141-146. https://pubmed.ncbi.nlm.nih.gov/21301759/
Urrútia, G., & Bonfill, X. (2010). Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica, 135(11), 507-511. https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-declaracion-prisma-una-propuesta-mejorar-S0025775310001454
Wang, Y., Springer, S., Mulvey, C. L, Silliman, N., Schaefer, J., Sausen, M., James, N., Rettig, E. M., Guo, T., Pickering, C. R., Bishop, J. A., Chung, C. H., Califano, J. A., Eisele, D. W., Fakhry, C., Gourin, C. G., Ha, P. K., Kang, H., Kiess, A., Koch, W. M., Myers, J. N., Quon, H., Richmon, J. D., Sidransky, D., Tufano, R. P., Westra, W. H., Bettegowda, C., Diaz, L. A. Jr., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Agrawal, N. (2015). Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Science translational medicine, 7(293), 293ra104-293ra104. https://doi.org/10.1126/scitranslmed.aaa8507
Akbulut, N., & Altan, A. (2018). Early Detection and Multidisciplinary Approach to Oral Cancer Patients. En S. Sundaresan (Ed.), Prevention, Detection and Management of Oral Cancer. IntechOpen. https://doi.org/10.5772/intechopen.81126
Badaracco, G., Venuti, A., Di Lonardo, A., Scambia, G., Mozzetti, S., Panici, P. B. & Marcante, M. L. (1998). Concurrent HPV infection in oral and genital mucosa. Journal of oral pathology & medicine, 27(3), 130-134. https://doi.org/10.1111/j.1600-0714.1998.tb01928.x
Brondani, M. A., Siqueira, A. B., & Alves, C. M. C. (2019). Exploring lay public and dental professional knowledge around HPV transmission via oral sex and oral cancer development. BMC public health, 19(1), 1529. https://doi.org/10.1186/s12889-019-7923-6
Broutian, T. R., He, X., & Gillison, M. L. (2011). Automated high throughput DNA isolation for detection of human papillomavirus in oral rinse samples. Journal of clinical virology, 50(4), 270-275. https://doi.org/10.1016/j.jcv.2010.12.005
Bustamante Ramos, G. M., Martínez Sánchez, A., Tenahua Quitl, I., Jiménez, C. & López Mendoza, Y. (2015). Conocimiento y prácticas de prevención sobre el virus del papiloma humano (VPH) en universitarios de la Sierra Sur, Oaxaca. Anales de la Facultad de Medicina, 76(4), 369-376. UNMSM. Facultad de Medicina. https://doi.org/10.15381/anales.v76i4.11406
Cameron, J. E., Snowhite, I. V., Chaturvedi, A. K., & Hagensee, M. E. (2003). Human papillomavi- rus-specific antibody status in oral fluids modestly reflects serum status in human immunodeficiency virus-positive individuals. Clin. Diagn. Lab. Immunol., 10(3), 431-438. https://doi.org/10.1128/cdli.10.3.431-438.2003
Dang, J., Feng, Q., Eaton, K. D., Jang, H. & Kiviat, N. B. (2015). Detection of HPV in oral rinse samples from OPSCC and non-OPSCC patients. BMC oral health, 15(1), 126. https://doi.org/10.1186/s12903-015-0111-x
Flake, C., Arafa, J., Hall, A., Ence, E., Howard, K. & Kingsley, K. (2012). Screening and detection of human papillomavirus (HPV) high-risk strains HPV16 and HPV18 in saliva samples from subjects under 18 years old in Nevada: a pilot study. BMC oral health, 12(1), 43. https://doi.org/10.1186/1472-6831-12-43
Gillison, M. L., Broutian, T., Pickard, R. K., Tong, Z. Y., Xiao, W., Kahle, L. & Chaturvedi, A. K. (2012). Prevalence of oral HPV infection in the United States, 2009-2010. Jama, 307(7), 693-703. https://doi.org/10.1001%2Fjama.2012.101
Hanna, G. J., Lau, C. J., Mahmood, U., Supplee, J. G., Mogili, A. R., Haddad, R. I., Jänne, P. A. & Paweletz, C. P. (2019). Salivary HPV DNA informs locoregional disease status in advanced HPV-associated oropharyngeal cancer. Oral oncology, 95, 120-126. https://doi.org/10.1016/j.oraloncology.2019.06.019
Holly, C., Salmond, S., & Saimbert, M. (2016). Comprehensive Systematic Review for Advanced Practice Nursing (2a ed.). New York: Springer Publishing Company. https://doi.org/10.1891/9780826131867
Karita, H. C. S., Magaret, A., Huang, M. L., Jerome, K. R., Feng, Q. & Wald, A. (2020). Quantitative oral hpv16 and hpv18 detection in persons attending dental clinics. Sexually Transmitted Diseases, 47(2), 100-104. https://doi.org/10.1097/olq.0000000000001097
Knight, G., & Roberts, B. (2020). Awareness of oral and genital human papillomavirus (HPV) infection in young adolescents prior to gender-neutral vaccination. BMJ Sexual & Reproductive Health. 2020 Apr 2: bmjsrh-2019-200410. https://doi.org/10.1136/bmjsrh-2019-200410
Kreimer, A. R., Campbell, C. M. P., Lin, H. Y., Fulp, W., Papenfuss, M. R., Abrahamsen, M. & Giuliano, A. R. (2013). Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. The Lancet, 382(9895), 877-887. https://doi.org/10.1016/s0140-6736(13)60809-0
Parker, K. H., Kemp, T. J., Pan, Y., Yang, Z., Giuliano, A. R., & Pinto, L. A. (2018). Evaluation of HPV-16 and HPV-18 specific antibody measurements in saliva collected in oral rinses and merocel® sponges. Vaccine, 36(19), 2705-2711. https://doi.org/10.1016/j.vaccine.2018.03.034
Pérez-Quintanilla M, Méndez-Martínez R, Vázquez-Vega S, Espinosa-Romero R, Sotelo-Regil R, Pérez-Montiel MD, et al. (2020) High prevalence of human papillomavirus and European vari- ants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women. PLoS ONE, 15(4), e0227900, 1-14. https://doi.org/10.1371/journal.pone.0227900
Pickard, R. K., Xiao, W., Broutian, T. R., He, X. & Gillison, M. L. (2012). The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sexually transmitted diseases, 39(7), 559-566. https://doi.org/10.1097/olq.0b013e31824f1c65
Sánchez Vargas, L. O., Díaz Hernández, C., & Martinez Martinez, A. (2010). Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices. Infectious agents and cancer, 5(1), 1-6. https://doi.org/10.1186%2F1750-9378-5-25
Sayyah Melli, M., Kazemi Sheshvan, M., Bonyadi, M., Ouladsahebmadarek, E., Dasranj Tabrizi, A., Ghojazadeh, M. & Mostafa-Gharabaghi, P. (2011). Detection of human papillomavirus in the saliva of women with concurrent human papillomavirus related genital lesions. Saudi medical journal, 32(2), 141-146. https://pubmed.ncbi.nlm.nih.gov/21301759/
Urrútia, G., & Bonfill, X. (2010). Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica, 135(11), 507-511. https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-declaracion-prisma-una-propuesta-mejorar-S0025775310001454
Wang, Y., Springer, S., Mulvey, C. L, Silliman, N., Schaefer, J., Sausen, M., James, N., Rettig, E. M., Guo, T., Pickering, C. R., Bishop, J. A., Chung, C. H., Califano, J. A., Eisele, D. W., Fakhry, C., Gourin, C. G., Ha, P. K., Kang, H., Kiess, A., Koch, W. M., Myers, J. N., Quon, H., Richmon, J. D., Sidransky, D., Tufano, R. P., Westra, W. H., Bettegowda, C., Diaz, L. A. Jr., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Agrawal, N. (2015). Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Science translational medicine, 7(293), 293ra104-293ra104. https://doi.org/10.1126/scitranslmed.aaa8507
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2022-06-06
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Cano Verdugo, G., Onofre Rodríguez, D. J., & Benavides Torres, R. A. (2022). Detecção do HPV na cavidade oral: uma revisão sistemática. Cuidado Multidisciplinario De La Salud BUAP, 3(6), 36–49. Recuperado de http://rd.buap.mx/ojs-dm/index.php/cmsj/article/view/828
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Los derechos morales pertenecen al autor, los derechos patrimoniales a la Benemérita Universidad Autónoma de Puebla.
