HPV Detection in the Oral Cavity: A Systematic Review
Keywords:
Oral HPV, prevalence, limitations, opportunity areas
Abstract
Introduction. HPV testing in the oral cavity has gained vital importance as an alternative method to traditional techniques since the end of last century; however, it is rarely described in the literature about the prevalence of oral HPV, and the limitations and opportunity areas around its application.
Objectives. Reviewing updated information about oral HPV testing, HPV prevalence, and the limitations and opportunity areas around oral HPV detection tests.
Methodology. A systematic review was carried out in PubMed with articles published between 1998-2020, indexed in JCR, following the PRISMA statement and steps proposed by Holly, Salmon and Saimbert (2016). The articles were selected according to a heading which contained inclusion criteria. Data analysis was narratively synthesized and the outcome was tabulated individually in an Excel table.
Results. A total of 16 articles were included, identifying the prevalence of HPV in the oral cavity in 6.9%, lack of literature and knowledge about the subject as limitations, and opportunity areas such as the creation of new oral HPV detection methods.
Conclusions. HPV testing in the oral cavity is a good alternative compared to conventional tests, however, there is a lack of information regarding its dissemination, awareness must be raised in patients and health workers so they know about the subject and implement it. Creation of new oral HPV detection methods must be worked on.
References
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Pickard, R. K., Xiao, W., Broutian, T. R., He, X. & Gillison, M. L. (2012). The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sexually transmitted diseases, 39(7), 559-566. https://doi.org/10.1097/olq.0b013e31824f1c65
Sánchez Vargas, L. O., Díaz Hernández, C., & Martinez Martinez, A. (2010). Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices. Infectious agents and cancer, 5(1), 1-6. https://doi.org/10.1186%2F1750-9378-5-25
Sayyah Melli, M., Kazemi Sheshvan, M., Bonyadi, M., Ouladsahebmadarek, E., Dasranj Tabrizi, A., Ghojazadeh, M. & Mostafa-Gharabaghi, P. (2011). Detection of human papillomavirus in the saliva of women with concurrent human papillomavirus related genital lesions. Saudi medical journal, 32(2), 141-146. https://pubmed.ncbi.nlm.nih.gov/21301759/
Urrútia, G., & Bonfill, X. (2010). Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica, 135(11), 507-511. https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-declaracion-prisma-una-propuesta-mejorar-S0025775310001454
Wang, Y., Springer, S., Mulvey, C. L, Silliman, N., Schaefer, J., Sausen, M., James, N., Rettig, E. M., Guo, T., Pickering, C. R., Bishop, J. A., Chung, C. H., Califano, J. A., Eisele, D. W., Fakhry, C., Gourin, C. G., Ha, P. K., Kang, H., Kiess, A., Koch, W. M., Myers, J. N., Quon, H., Richmon, J. D., Sidransky, D., Tufano, R. P., Westra, W. H., Bettegowda, C., Diaz, L. A. Jr., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Agrawal, N. (2015). Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Science translational medicine, 7(293), 293ra104-293ra104. https://doi.org/10.1126/scitranslmed.aaa8507
Akbulut, N., & Altan, A. (2018). Early Detection and Multidisciplinary Approach to Oral Cancer Patients. En S. Sundaresan (Ed.), Prevention, Detection and Management of Oral Cancer. IntechOpen. https://doi.org/10.5772/intechopen.81126
Badaracco, G., Venuti, A., Di Lonardo, A., Scambia, G., Mozzetti, S., Panici, P. B. & Marcante, M. L. (1998). Concurrent HPV infection in oral and genital mucosa. Journal of oral pathology & medicine, 27(3), 130-134. https://doi.org/10.1111/j.1600-0714.1998.tb01928.x
Brondani, M. A., Siqueira, A. B., & Alves, C. M. C. (2019). Exploring lay public and dental professional knowledge around HPV transmission via oral sex and oral cancer development. BMC public health, 19(1), 1529. https://doi.org/10.1186/s12889-019-7923-6
Broutian, T. R., He, X., & Gillison, M. L. (2011). Automated high throughput DNA isolation for detection of human papillomavirus in oral rinse samples. Journal of clinical virology, 50(4), 270-275. https://doi.org/10.1016/j.jcv.2010.12.005
Bustamante Ramos, G. M., Martínez Sánchez, A., Tenahua Quitl, I., Jiménez, C. & López Mendoza, Y. (2015). Conocimiento y prácticas de prevención sobre el virus del papiloma humano (VPH) en universitarios de la Sierra Sur, Oaxaca. Anales de la Facultad de Medicina, 76(4), 369-376. UNMSM. Facultad de Medicina. https://doi.org/10.15381/anales.v76i4.11406
Cameron, J. E., Snowhite, I. V., Chaturvedi, A. K., & Hagensee, M. E. (2003). Human papillomavi- rus-specific antibody status in oral fluids modestly reflects serum status in human immunodeficiency virus-positive individuals. Clin. Diagn. Lab. Immunol., 10(3), 431-438. https://doi.org/10.1128/cdli.10.3.431-438.2003
Dang, J., Feng, Q., Eaton, K. D., Jang, H. & Kiviat, N. B. (2015). Detection of HPV in oral rinse samples from OPSCC and non-OPSCC patients. BMC oral health, 15(1), 126. https://doi.org/10.1186/s12903-015-0111-x
Flake, C., Arafa, J., Hall, A., Ence, E., Howard, K. & Kingsley, K. (2012). Screening and detection of human papillomavirus (HPV) high-risk strains HPV16 and HPV18 in saliva samples from subjects under 18 years old in Nevada: a pilot study. BMC oral health, 12(1), 43. https://doi.org/10.1186/1472-6831-12-43
Gillison, M. L., Broutian, T., Pickard, R. K., Tong, Z. Y., Xiao, W., Kahle, L. & Chaturvedi, A. K. (2012). Prevalence of oral HPV infection in the United States, 2009-2010. Jama, 307(7), 693-703. https://doi.org/10.1001%2Fjama.2012.101
Hanna, G. J., Lau, C. J., Mahmood, U., Supplee, J. G., Mogili, A. R., Haddad, R. I., Jänne, P. A. & Paweletz, C. P. (2019). Salivary HPV DNA informs locoregional disease status in advanced HPV-associated oropharyngeal cancer. Oral oncology, 95, 120-126. https://doi.org/10.1016/j.oraloncology.2019.06.019
Holly, C., Salmond, S., & Saimbert, M. (2016). Comprehensive Systematic Review for Advanced Practice Nursing (2a ed.). New York: Springer Publishing Company. https://doi.org/10.1891/9780826131867
Karita, H. C. S., Magaret, A., Huang, M. L., Jerome, K. R., Feng, Q. & Wald, A. (2020). Quantitative oral hpv16 and hpv18 detection in persons attending dental clinics. Sexually Transmitted Diseases, 47(2), 100-104. https://doi.org/10.1097/olq.0000000000001097
Knight, G., & Roberts, B. (2020). Awareness of oral and genital human papillomavirus (HPV) infection in young adolescents prior to gender-neutral vaccination. BMJ Sexual & Reproductive Health. 2020 Apr 2: bmjsrh-2019-200410. https://doi.org/10.1136/bmjsrh-2019-200410
Kreimer, A. R., Campbell, C. M. P., Lin, H. Y., Fulp, W., Papenfuss, M. R., Abrahamsen, M. & Giuliano, A. R. (2013). Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. The Lancet, 382(9895), 877-887. https://doi.org/10.1016/s0140-6736(13)60809-0
Parker, K. H., Kemp, T. J., Pan, Y., Yang, Z., Giuliano, A. R., & Pinto, L. A. (2018). Evaluation of HPV-16 and HPV-18 specific antibody measurements in saliva collected in oral rinses and merocel® sponges. Vaccine, 36(19), 2705-2711. https://doi.org/10.1016/j.vaccine.2018.03.034
Pérez-Quintanilla M, Méndez-Martínez R, Vázquez-Vega S, Espinosa-Romero R, Sotelo-Regil R, Pérez-Montiel MD, et al. (2020) High prevalence of human papillomavirus and European vari- ants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women. PLoS ONE, 15(4), e0227900, 1-14. https://doi.org/10.1371/journal.pone.0227900
Pickard, R. K., Xiao, W., Broutian, T. R., He, X. & Gillison, M. L. (2012). The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18–30 years. Sexually transmitted diseases, 39(7), 559-566. https://doi.org/10.1097/olq.0b013e31824f1c65
Sánchez Vargas, L. O., Díaz Hernández, C., & Martinez Martinez, A. (2010). Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices. Infectious agents and cancer, 5(1), 1-6. https://doi.org/10.1186%2F1750-9378-5-25
Sayyah Melli, M., Kazemi Sheshvan, M., Bonyadi, M., Ouladsahebmadarek, E., Dasranj Tabrizi, A., Ghojazadeh, M. & Mostafa-Gharabaghi, P. (2011). Detection of human papillomavirus in the saliva of women with concurrent human papillomavirus related genital lesions. Saudi medical journal, 32(2), 141-146. https://pubmed.ncbi.nlm.nih.gov/21301759/
Urrútia, G., & Bonfill, X. (2010). Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Medicina clínica, 135(11), 507-511. https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-declaracion-prisma-una-propuesta-mejorar-S0025775310001454
Wang, Y., Springer, S., Mulvey, C. L, Silliman, N., Schaefer, J., Sausen, M., James, N., Rettig, E. M., Guo, T., Pickering, C. R., Bishop, J. A., Chung, C. H., Califano, J. A., Eisele, D. W., Fakhry, C., Gourin, C. G., Ha, P. K., Kang, H., Kiess, A., Koch, W. M., Myers, J. N., Quon, H., Richmon, J. D., Sidransky, D., Tufano, R. P., Westra, W. H., Bettegowda, C., Diaz, L. A. Jr., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Agrawal, N. (2015). Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Science translational medicine, 7(293), 293ra104-293ra104. https://doi.org/10.1126/scitranslmed.aaa8507
Published
2022-06-06
How to Cite
Cano Verdugo, G., Onofre Rodríguez, D. J., & Benavides Torres, R. A. (2022). HPV Detection in the Oral Cavity: A Systematic Review . Cuidado Multidisciplinario De La Salud BUAP, 3(6), 36-49. Retrieved from http://rd.buap.mx/ojs-dm/index.php/cmsj/article/view/828
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Literature Review
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