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Articles

Año 8 No. 23 Mayo - Agosto 2022

HOW BACTERIA SENSE ENVIRONMENTAL SIGNALS?

DOI
https://doi.org/10.32399/icuap.rdic.2448-5829.2022.23.813
Submitted
June 19, 2022
Published
June 20, 2022

Abstract

Bacteria are perhaps the most ubiquitous microorganisms on the planet, we can find them practically everywhere, successfully adapting to environments as different as the human stomach and the water tap. In order to adapt and survive, they need to perceive and respond to environmental conditions. Unlike animals and plants that have specialized organs and systems to be able to detect and respond to the environment, bacteria are able to adapt with apparently very simple but very efficient mechanisms, turning these into their five senses. These bacterial detection mechanisms are known as two-component signal transduction systems. In this article, we review the basic aspects of how these systems work, as well as the importance of understanding them with the aim of using this knowledge, for example, in the treatment of infections. bacteria and in the use of beneficial bacteria of biotechnological interest.

Key words: Two component system, signal transduction, multicomponent systems

References

  1. Appleby, J. L., Parkinson, J. S., & Bourret, R. B. (1996). Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Traveled. Cell, 86(6), 845– 848. https://doi.org/10.1016/S0092-8674(00)80158-0
  2. Barakat, M., Ortet, P., & Whitworth, D. E. (2011). P2CS: a database of prokaryotic two-component systems. Nucleic acids research, 39(Database issue), D771–D776. https://doi.org/10.1093/nar/gkq1023
  3. Bhagirath AY, Pydi SP, Li Y, Lin C, Kong W, et al. (2017) Characterization of the direct interaction between hybrid sensor kinases PA1611 and RetS that controls biofilm formation and the type III secretion system in Pseudomonas aeruginosa. ACS Infect. Dis. 3:162–75. DOI: 10.1021/acsinfecdis.6b00153
  4. Casino P, Rubio V, Marina A (2009) Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction. Cell 139:325-336.
  5. Cheung; J & A. Hendrickson; W. (2010). Sensor domains of two-component regulatory systems. Current Opinion in microbiology. 13:116–123. DOI: 10.1016/j.cell.2009.08.032.
  6. Francis VI, Waters EM, Finton-James SE, Gori A, Kadioglu A, et al. (2018). Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. Nat. Commun. 9:2219. https://www.nature.com/articles/s41467-018-04640-8
  7. Gao R, Stock AM. (2009) Biological insights from structures of two-component proteins. Annu Rev Microbiol. 63:133-54. doi: 10.1146/annurev.micro.091208.073214.
  8. Goodman AL, Kulasekara B, Rietsch A, Boyd D, Smith RS, Lory S. (2004). A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev. Cell 7:745–54. DOI: 10.1016/j.devcel.2004.08.020
  9. Gumerov VM, Ortega DR, Adebali O, Ulrich LE, and Zhulin IB (2020) MiST 3.0: an updated microbial signal transduction database with an emphasis on chemosensory systems. Nucleic Acids Research,48: D459–D464. https://doi.org/10.1093/nar/gkz988.
  10. Henke JM, Bassler BL. (2004). Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J. Bacteriol. 186:3794–805. DOI: 10.1128/JB.186.12.3794-3805.2004.
  11. Kong W, Chen L, Zhao J, Shen T, Surette MG, et al. (2013). Hybrid sensor kinase PA1611 in Pseudomonas aeruginosa regulates transitions between acute and chronic infection through direct interaction with RetS. Mol. Microbiol. 88:784–97. DOI: 10.1111/mmi.12223.
  12. Swartzman E, Silverman M, Meighen EA. (1992). The luxR gene product of Vibrio harveyi is a transcriptional activator of the lux promoter. J. Bacteriol. 174:7490–93. DOI: 10.1128/jb.174.22.7490-7493.1992.
  13. Ulrich LE, Zhulin IB.(2010). The MiST2 database: a comprehensive genomics resource on microbial signal transduction. Nucleic Acids Res; 38:D401–7. https://pubmed.ncbi.nlm.nih.gov/19900966/
  14. Wolanin, P. M., Thomason, P. A., & Stock, J. B. (2002). Histidine protein kinases: key signal transducers outside the animal kingdom. Genome Biology, 3(10), reviews3013.1. https://doi.org/10.1186/gb-2002-3-10-reviews3013