The skin is the outer layer of the human body that serves as a barrier against various environmental agents, the ultraviolet (UV) radiation emitted by the sun is absorbed in the epidermis causing damage such as blemishes, irritations, melanomas and wrinkles, so its protection based on photoprotective compounds and lightening treatments are necessary. Conventional cosmetic products are based on a chemical composition and synthesis where some of these compounds can be harmful to the skin and its microbiota. A solution and proposal to these elements is the use of natural products, focusing on the microorganisms present in the skin that have probiotic properties and produce photoprotective and lightening metabolites. This manuscript discusses the mechanism of photoprotection, and lightening associated with different microorganisms and their potential for production on an industrial scale.