Artículos
Vol. 10 (2024): Número Especial de Posgrados ICUAP
DE HÉROE A VILLANO: GADOLINIO EN EL DIAGNÓSTICO DE VANGUARDIA COMO REDENCIÓN A UNA EMERGENTE CONTAMINACIÓN
Centro de Química del Instituto de Ciencias Benemérita Universidad Autónoma de Puebla
Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla
Resumen
Los complejos de gadolinio son los agentes de contraste más utilizados en estudios de imagenología por resonancia magnética. Estos compuestos son excretados sin metabolizar a través de la orina y circulan en el drenaje donde son propensos a experimentar cambios en su estructura química que propician la liberación del ion gadolinio, que es altamente tóxico. Sin embargo, en forma de complejo o de ion es considerado un contaminante emergente en los cuerpos de agua. El objetivo de esta contribución es evidenciar la problemática ambiental que representa la disposición inadecuada de los agentes de contraste basados en gadolinio.
Citas
Alvarez Aguiñaga, E. A. (2023). Preparación de materiales para el tratamiento de gadoterato de meglumina. Benemérita Universidad Autónoma de Puebla.
Alvarez-Aguiñaga, E. A., Elizalde-González, M. P., García-Díaz, E., & Sabinas-Hernández, S. A. (2022). UV-light-driven conversion of gadoterate meglumine: Insight into the photocatalyst’s influence on conversion pathway, transformation products, and release of toxic ionic gadolinium. Catalysis Communications, 172. https://doi.org/10.1016/j.catcom.2022.106544
Bao, Y., Sherwood, J. A., & Sun, Z. (2018). Magnetic iron oxide nanoparticles as: T 1 contrast agents for magnetic resonance imaging. In Journal of Materials Chemistry C (Vol. 6, Issue 6, pp. 1280–1290). Royal Society of Chemistry. https://doi.org/10.1039/c7tc05854c
Birch, G. F., Drage, D. S., Thompson, K., Eaglesham, G., & Mueller, J. F. (2015). Emerging contaminants (pharmaceuticals, personal care products, a food additive and pesticides) in waters of Sydney estuary, Australia. Marine Pollution Bulletin, 97(1–2), 56–66. https://doi.org/10.1016/j.marpolbul.2015.06.038
Brünjes, R., & Hofmann, T. (2020). Anthropogenic gadolinium in freshwater and drinking water systems. Water Research, 182. https://doi.org/10.1016/j.watres.2020.115966
Dávila-Jiménez, M. M., Elizalde-González, M. P., Guerrero-Morales, M. A., & Mattusch, J. (2018). Preparation, characterization, and application of TiO2/Carbon composite: Adsorption, desorption and photocatalysis of Gd-DOTA. Process Safety and Environmental Protection, 120, 195–205. https://doi.org/10.1016/j.psep.2018.09.012
Ebrahimi, P., & Barbieri, M. (2019). Gadolinium as an emerging microcontaminant in water resources: Threats and opportunities. In Geosciences (Switzerland) (Vol. 9, Issue 2). MDPI AG. https://doi.org/10.3390/geosciences9020093
Elizalde-González, M. P., García-Díaz, E., González-Perea, M., & Mattusch, J. (2017). Removal of gadolinium-based contrast agents: adsorption on activated carbon. Environmental Science and Pollution Research, 24(9), 8164–8175. https://doi.org/10.1007/s11356-017-8491-x
Ernie Tretkoff. (2024, February 6). MRI Uses Fundamental Physics for Clinical Diagnosis. APS.
Kim, H. K., Lee, G. H., & Chang, Y. (2018). Gadolinium as an MRI contrast agent. In Future Medicinal Chemistry (Vol. 10, Issue 6, pp. 639–661). Future Medicine Ltd. https://doi.org/10.4155/fmc-2017-0215
Kuroda, K., Itten, R., Kovalova, L., Ort, C., Weissbrodt, D. G., & McArdell, C. S. (2016). Hospital-use pharmaceuticals in swiss waters modeled at high spatial resolution. Environmental Science and Technology, 50(9), 4742–4751. https://doi.org/10.1021/acs.est.6b00653
Le Fur, M., & Caravan, P. (2019). The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists. Metallomics, 11(2), 240–254. https://doi.org/10.1039/c8mt00302e
Liang, Z.-P., & Lauterbur, P. C. (2000). Principles of magnetic resonance imaging. A signal processing perspective (1st ed.). Wiley.
Lohrke, J., Frenzel, T., Endrikat, J., Alves, F. C., Grist, T. M., Law, M., Lee, J. M., Leiner, T., Li, K. C., Nikolaou, K., Prince, M. R., Schild, H. H., Weinreb, J. C., Yoshikawa, K., & Pietsch, H. (2016). 25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives. In Advances in Therapy (Vol. 33, Issue 1, pp. 1–28). Springer Healthcare. https://doi.org/10.1007/s12325-015-0275-4
Rogowska, J., Olkowska, E., Ratajczyk, W., & Wolska, L. (2018). Gadolinium as a new emerging contaminant of aquatic environments. In Environmental Toxicology and Chemistry (Vol. 37, Issue 6, pp. 1523–1534). Wiley Blackwell. https://doi.org/10.1002/etc.4116
Xiao, Y. D., Paudel, R., Liu, J., Ma, C., Zhang, Z. S., & Zhou, S. K. (2016). MRI contrast agents: Classification and application. International Journal of Molecular Medicine, 38(5), 1319–1326. https://doi.org/10.3892/ijmm.2016.2744