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Extensive research in cancer has led to the development of more specific therapies against tumor cells. Monoclonal antibodies are highly specific recombinant proteins, produced by the fusion of B lymphocytes and myelomas. They can recognize and bind to antigens, so they have been applied to the areas of biology, biotechnology, immunotherapy, and health sciences. Monoclonal antibodies have been used to develop cancer therapies because they can inhibit signals for tumor growth and induce responses towards the destruction of tumor cells. This application is known as immunobiotechnology. The potential application of monoclonal antibodies has produced three generations of these proteins, which have continuously evolved to improve their effectiveness, making this type of technology one of the greatest areas of developmentin pharmacy and biotechnology. Recently, the development of monoclonal antibodies has been focused on the most common types of cancer in people.