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Articles

Año 6 No. 18 Septiembre - Diciembre 2020

The potential of diosgenin in the medical field

DOI
https://doi.org/10.32399/icuap.rdic.2448-5829.2020.18.244
Submitted
October 24, 2020
Published
October 24, 2020

Abstract

Saponins are a large group of amphipathic molecules distributed in a considerable number of vascular plants, among which tubers belonging to the genus Dioscorea are notable. Their structure is composed of a hydrophilic moiety and a hydrophobic moiety, called sapogenin. The latter group includes diosgenin, which has been widely used in the medical field, for example, as a typical precursor of steroidal drugs. Therefore, the main purpose of this article is to present recent information on the applications of diosgenin, focusing on three areas of medical interest—cancer, biomaterials and Alzheimer’s disease—in order to display the clinical potential of this molecule.

References

  1. Alcantara, E. H.; Shin, M. Y.; Sohn, H. Y.; Park, Y. M.; Kim, T.; Lim, J. H.; … Kwun, I. S. (2011). Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. Journal of Nutritional Biochemistry, 22(11), 1055-1063. https://doi.org/10.1016/j.jnutbio.2010.09.003.
  2. Bose, S. y Bandyopadhyay, A. (2013). Introduction to Biomaterials. En Characterization of Biomaterials. https://doi.org/10.1016/B978-0-12-415800-9.00001-2.
  3. Chen, Y.; Tang, Y. M.; Yu, S. L.; Han, Y. W.; Kou, J. P.; Liu, B. L. y Yu, B. Y. (2015). Advances in the pharmacological activities and mechanisms of diosgenin. Chinese Journal of Natural Medicines, 13(8), 578-587. https://doi.org/10.1016/S1875-5364(15)30053-4.
  4. Desai, S. D.; Desai, D. G. y Kaur, H. (2009). Saponins and their biological activities. Pharma Times, 41(3), 13-16.
  5. Drahansky, M.; Paridah, M.; Moradbak, A.; Mohamed, A.; Owolabi, F.; Abdulwahab Taiwo; Asniza, M. y Abdul Khalid, S. H. (2016). Polymerization of Peptide Polymers for Biomaterial Applications. Intech, i(Turismo), 13. https://doi.org/http://dx.doi.org/10.5772/57353.
  6. Fernández, A.; Castellanos, L. y Ortega, I. (2015). Efectividad del extracto de Furcraea hexapetala (Jacq.) Urban sobre áfidos y ácaros fitófagos. Revista Científica Agroecosistemas, 3(1), 2015.
  7. Gobbi, S. J. (2019). Requirements for Selection/Development of a Biomaterial. Biomedical Journal of Scientific & Technical Research, 14(3). https://doi.org/10.26717/bjstr.2019.14.002554.
  8. Iván, A. y Parra, R. (2004). Historia de la Ginecología y Obstetricia: Pasado, Presente y Futuro de las Progestinas (Past, Present and Future of Progestogens). Revista Colombiana de Obstetricia y Ginecología, 55(2), 167-173. Recuperado de: http://www.scielo.org.co/pdf/rcog/v55n2/v55n2a09.pdf.
  9. Jesus, M.; Martins, A. P. J.; Gallardo, E. y Silvestre, S. (2016). Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology. Journal of Analytical Methods in Chemistry, 2016. https://doi.org/10.1155/2016/4156293.
  10. Liao, A. M.; Jung, H.; Yu, J. W.; Lee, D. H.; Park, S. S.; Cai, B. y Chun, C. J. (2018). Synthesis and biological evaluation of arginyl-diosgenin conjugate as a potential bone tissue engineering agent. Chemical Biology and Drug Design, 91(1), 17-28. https://doi.org/10.1111/cbdd.13050.
  11. López Locanto, Ó. (2015). Tratamiento farmacológico de la enfermedad de Alzheimer y otras demencias. Archivos de Medicina Interna, 37(2), 61-67.
  12. Martínez, A. (2001). Saponinas esteroides. Medicine, 1-22.
  13. Miramontes, L. E. (2001). Industria de los esteroides en Mexico. Revista de La Sociedad Química de México, 45(3), 102-104. Recuperado de: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0583-76932001000300003&lng=en&nrm=iso&tlng=es.
  14. Mohamed, M.; El, A.; Ashour, A. S.; Sadek, A. y Melad, G. (2019). A review on saponins from medicinal plants: chemistry , isolation , and determination. Journal of Nanomedicine Research, 8(1), 6-12. https://doi.org/10.15406/jnmr.2019.08.00199.
  15. Podolak, I.; Galanty, A. y Sobolewska, D. (2010). Saponins as cytotoxic agents: A review. Phytochemistry Reviews, Vol. 9, pp. 425-474. https://doi.org/10.1007/s11101-010-9183-z.
  16. Porras, A. y Marzo, I. (2010). SEBBM DIVULGACIÓN Apoptosis: una forma controlada de muerte. Universidad Complutense / Dpto. de Bioquímica y Biología Molecular y Celular, 1(1), 1-2. https://doi.org/10.18567/sebbmdiv_RPC.2010.05.1.
  17. Ratner, B. D. (2019). Biomaterials: Been There, Done That, and Evolving into the Future. Annual Review of Biomedical Engineering, 21(1), 171-191. https://doi.org/10.1146/annurev-bioeng-062117-120940.
  18. Sethi, G.; Shanmugam, M. K.; Warrier, S.; Merarchi, M.; Arfuso, F.; Kumar, A. P. y Bishayee, A. (2018). Pro-apoptotic and anti-cancer properties of diosgenin: A comprehensive and critical review. Nutrients, Vol. 10, 19 de mayo de 2018. https://doi.org/10.3390/nu10050645.
  19. Sidhu, S. S. (2019). Biomaterials in Orthopaedics and Bone Regeneration (P. S. Bains, S. S. Sidhu, M. Bahraminasab y C. Prakash, Eds.). https://doi.org/10.1007/978-981-13-9977-0.
  20. Tohda, C. (2016). New age therapy for Alzheimer’s disease by neuronal network reconstruction. Biological and Pharmaceutical Bulletin, 39(10), 1569-1575. https://doi.org/10.1248/bpb.b16-00438.
  21. Tohda, C.; Urano, T.; Umezaki, M.; Nemere, I. y Kuboyama, T. (2012). Diosgenin is an exogenous activator of 1,25D 3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Scientific Reports, 2, 1-11. https://doi.org/10.1038/srep00535.
  22. Tolar, M.; Abushakra, S. y Sabbagh, M. (2019). The path forward in Alzheimer’s disease therapeutics: Reevaluating the amyloid cascade hypothesis. Alzheimer’s & Dementia, 1-8. https://doi.org/10.1016/j.jalz.2019.09.075.
  23. Tong, Q. Y.; He, Y.; Zhao, Q. B.; Qing, Y.; Huang, W. y Wu, X. H. (2012). Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells. Steroids, 77(12), 1219-1227. https://doi.org/10.1016/j.steroids.2012.04.019.
  24. Valle, E. M. A. (2016). Caracterización de saponinas de Agave durangensis y salmiana , y su efecto en la pared y membrana celular de Kluyveromyces marxianus y Saccharomyces cerevisiae, 1-125.
  25. Vanessa, Q. F.; Londoño, G.; Susana, Q. F.; Villa, A.; Luisa, D.; Medina, O.; … Cardona, M. (2014). Actividad espermicida de saponinas esteroideas y triterpénicas extraídas de diferentes plantas. Revista Cubana de Plantas Medicinales, 19(1), 76-84. Recuperado de: http://scielo.sld.cuhttp//scielo.sld.cu.
  26. Yang, X. y Tohda, C. (2018). Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70). Scientific Reports, 8(1), 1-10. https://doi.org/10.1038/s41598-018-30102-8.
  27. Zeferino-Diaz, R.; Hilario-Martinez, J. C.; Rodriguez-Acosta, M.; Sandoval-Ramirez, J. y Fernandez-Herrera, M. A. (2015). 22-Oxocholestanes as plant growth promoters. Steroids, 98, 126-131. https://doi.org/10.1016/j.steroids.2015.03.005.
  28. Zetter, PhD, B. R. (1998). Angiogenesis and Tumor Metastasis. Annual Review of Medicine, 49(1), 407-424. https://doi.org/10.1146/annurev.med.49.1.407.