NANOMATERIALES DE CARBONO PARA LIBERACIÓN DE FÁRMACOS
DOI:
https://doi.org/10.32399/icuap.rdic.2448-5829.2024.Especial.1355Palabras clave:
Nanomateriales, liberación de fármacos, carbón, grafeno.Resumen
En los últimos años, el avance alcanzado en el desarrollo de las aplicaciones biomédicas se ha dado de forma significativa, debido principalmente, al gran esfuerzo que ha tenido la comunidad científica internacional en temas relacionados a la nanociencia y nanotecnología, en especial en el estudio y desarrollo de nanopartículas, las cuales son estructuras que tienen tamaños menores a los 100 nanómetros. Las nanopartículas están conformadas por unos pocos cientos de átomos, lo que genera que sus propiedades sean únicas y cambien considerablemente a nivel macrométrico. Dentro de la familia de materiales nanoestructurados, con propiedades únicas, se encuentran las nanopartículas de carbono, las cuales son muy versátiles debido a que presentan diferentes tipos de estructuras. Esto las convierte en extraordinarias opciones para su uso como transportadores de fármacos, lo cual las hace una prominente opción para su uso en el área oncológica, en especial para los tratamientos contra cáncer. En este trabajo exploramos el fascinante mundo de los nanomateriales, con propiedades excepcionales para la liberación de fármacos. Tales como las sorprendentes nanoestructuras de carbono, compuestas por nanotubos y grafeno, con resistencia y biocompatibilidad ideales para aplicaciones biomédicas. La importancia principal es que estos avances prometedores anticipan una revolución en el diagnóstico, tratamiento y prevención de enfermedades, lo cual en un futuro puede llegar a redefinir el futuro de la medicina.
Citas
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Chuyi H., Xianming Z., Fan W., Qinghua Y., Feng C., Di S., Zhangyou Y., Tingting W., Mingyue J., Tao D., Chao Y. (2021). Duplex Metal Co-Doped Carbon Quantum Dots-Based Drug Delivery System With Intelligent Adjustable Size As Adjuvant For Synergistic Cancer Therapy, Carbon 183 (789-808), https://doi.org/10.1016/j.carbon.2021.07.063.
Daphne E. S. M., Pharm D., B.C.-ADM, CDCES. (2023). University of Illinois at Chicago College of Pharmacy.
Deng T., Wang J., Li Y., Han Z., Peng Y., Zhang J., Gao Z., Gu Y., Deng D. (2018). Quantum Dots-Based Multifunctional Nano-Prodrug Fabricated by Ingenious Self-Assembly Strategies for Tumor Theranostic, ACS Appl. Mater. Interfaces 10 (27657e27668). https://doi.org/10.1021/acsami.8b08512.
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Huang X., Mclean R., Zheng M. (2005). High-Resolution Length Sorting And Purification Of DNA-Wrapped Carbon Nanotubes By Size-Exclusion Chromatography. Anal Chem 77(19) 6225-6228. https://doi.org/10.1021/acsnano.3c07668
Hua X.W., Bao Y.W., Chen Z., Wu F.G., (2017). Carbon Quantum Dots With Intrinsic Mitochondrial Targeting Ability for Mitochondria-Based Theranostics, Nanoscale 9 (10948e10960). https://doi.org/10.1039/c7nr03658b.
Irum R., Ayesha K., Zanib A, Bakhtiar M. (2016). Exploration of Epoxy Resins, Hardening Systems, and Epoxy/Carbon Nanotube Composite Designed for High Performance Materials: A Review, Polymer-Plastics Technology and Engineering, 55(3) 312-333. https://doi: 10.1080/03602559.2015.1070874
Juan P. G., Esdras A. Z.-M, Lourdes R.-F. (2022). Chapter, Advances in Graphene Platforms for Drug Delivery in Cancer and Its Biocompatibility. http://dx.doi.org/10.5772/intechopen.103688.
Jashandeep K., Gurlal S. G., Kiran J. (2019). Characterization And Biology Of Nanomaterials For Drug Delivery, chapter 5, Applications of Carbon Nanotubes in Drug Delivery: A Comprehensive Review. https://doi.org/10.1016/B978-0-12-814031-4.00005-2.
Lyra, K.., Kaminari, A., Panagiotaki, K.N., Spyrou, K., Papageorgiou, S., Sakellis, E., Katsaros, F.K., Sideratou, Z. (2021). Multi-Walled Carbon Nanotubes Decorated With Guanidinylated Dendritic Molecular Transporters: An Efficient Platform For The Selective Anticancer Activity Of Doxorubicin, Pharmaceutics. 13(858). https://doi.org/10.3390/pharmaceutics13060858.
Lijima S. (1991). Helical Microtubules of Graphitic Carbon. Nature 354, (6348-56). https://doi: 10.1038/354056a0.
Loera-Serna S, Ruiz-Angeles J, Flores-Moreno J, Soto-Portas L. (2012). Protegiendo fármacos con nanomateriales inteligentes. Mundo Nano. 5. https://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-56912012000100059
Maiti D., Tong X., Mou X., Yang K. (2019) Carbon-based Nanomaterials for Biomedical Applications: a Recent Study. Front Pharmacol, 9,(1–16). https://doi.org/10.3389/fphar.2018.01401
Mahor A., Singh P.P., Bharadwaj P., Sharma N., Yadav S., Rosenholm J.M , Bansal K.K, (2021), Carbon-based nanomaterials for delivery of biologicals and therapeutics: A cutting-edge technology, Journal of Carbon Research,, 7, 19. https://doi.org/10.3390/c7010019
Mohd N. N., Asyraf, M.R.M., Khalina, A., Abdullah, N., Sabaruddin, F.A., Kamarudin, S.H., Ahmad, S., Mahat, A.M., Lee, C.L., Aisyah, H.A. (2021). Fabrication, Functionalization, And Application Of Carbon Nanotube-Reinforced Polymer Composite: An Overview. Polymers 13(1047). https://doi.org/10.3390/polym13071047
Caracuel A. M., (2020) Sistemas de liberación controlada de fármacos obtenidos por impresión 3d. Mecanismos de liberación y factores que influyen, [Tesis de licenciatura, Universidad de Sevilla]. Deposito de investigación Universidad de Sevilla. https://hdl.handle.net/11441/103272
Nayab A., Murtaza N. A., Tooba J. K. (2021). Carbon Quantum Dots For Biomedical Applications: Review And Analysis, Front. Mater. 8 https://doi.org/10.3389/fmats.2021.700403.
PALIWAL S., PANDEY K., PAWAR S., JOSHI H., BISHT N. (2020). A Review On Carbon Nanotubes: As A Nano Carrier Drug Delivery System, Indian J Pharm Sci. 82(5):766-772.
Parand R. R., Roger J. N. (2021). Recent Advances in Carbon Nanomaterials for Biomedical Applications: A Review. Current Opinion in Biomedical Engineering, 17(100262), https://doi.org/10.1016/j.cobme.2021.100262.
Rao C., Govindaraj A., Gundiah G., Vivekchand S. (2004). Nanotubes And Nanowires. Chem Eng Sci. 59(4665). https://doi.org/10.1016/j.ces.2004.07.067.
Rojas-Aguirre Y., Aguado-Castrejón K., González-Méndez I., (2016) La nanomedicina y los sistemas de liberación de fármacos: ¿la revolución de la terapia contra el cáncer?, Educación Química,, 27, 286-291. https://doi.org/10.1016/j.eq.2016.07.002
Rummeli M., Borowiak-Palen E., Gemming T., Pichler T., Knupfer M., Kalbac M., Dunsch L., Jost O., Silva S., PompeW., Buchner B. (2005). Novel Catalysts, Room Temperature, And The Importance Of Oxygen For The Synthesis Of Single-Walled Carbon Nanotubes. Nano Lett 5(7) 1209-1215. https://doi: 10.1021/nl050692v
Shi J., Xiaoyuan Y., Lei W., Yan L., Jun G., Jing Z., Rou M., Ruiyuan L., Zhenzhong Z. (2013). Pegylated Fullerene/Iron Oxide Nanocomposites For Photodynamic Therapy, Targeted Drug Delivery And MR Imaging. Biomaterials 3437(9666-9677). https://doi.org/10.1016/j.biomaterials.2013.08.049
Vander Wal RL, Ticich TM, Curtis VE.(2000). Diffusion Flame Synthesis Of Single-Walled Carbon Nanotubes. Chem Phys Lett. 323(217-223). https://doi.org/10.1016/S0009-2614(00)00522-4.
Vázquez-Hernández F., Granada-Ramírez D.A., Arias-Cerón J.S., Rodriguez-Fragoso P., Mendoza-Álvarez J.G., Ramón-Gallegos E., Cruz-Orea A., Luna-Arias J.P., (2018). Use Of Nanostructured Materials In Drug Delivery, chapter 20, Nanobiomaterials https://doi.org/10.1016/B978-0-08-100716-7.00020-9
Wang Z., Colombi C. L., Wei G. (2017). Recent Advances In The Synthesis Of Graphene-Based Nanomaterials For Controlled Drug Delivery. Applied Sciences. 7(11) 1175. https://doi.org/10.3390/app7111175.
Wu H., Su W., Xu H. (2021). Applications Of Carbon Dots On Tumour Theranostics. VIEW. 2(20200061). https://doi.org/10.1002/VIW.20200061.
Xia Q., Zhang Z., Liu Y., Leng J. (2020). Buckypaper And Its Composites For Aeronautic Applications, Composites Part B: Engineering, 199 (108231). https://doi.org/10.1016/j.compositesb.2020.108231
Yoosefian M., Jahani M. (2019). A Molecular Study On Drug Delivery System Based On Carbon Nanotube For The Novel Norepinephrine Prodrug, Droxidopa. J Mol Liq. 284:258–264. https://doi.org/10.1016/j.molliq.2019.04.016
Zahra S. (2021). Journal of Drug Delivery Science and Technology 66 (102790) https://doi.org/10.1016/j.jddst.2021.102790.
Zhang C., Wu L., de Perrot M., Zhao X. (2021). Carbon Nanotubes: A Summary Of Beneficial And Dangerous Aspects Of An Increasingly Popular Group Of Nanomaterials, Front. Oncol. 11(693814). doi: 10.3389/fonc.2021.693814.
Adrita, S.H.; Tasnim, K.N.; Ryu, J.H.; Sharker, S.M. (2020). Nanotheranostic Carbon Dots as an Emerging Platform for Cancer Therapy. J. Nanotheranostics. 1 (58-77). https://doi.org/10.3390/jnt1010006.
Contreras-Camach M., Martínez-Luevanos A.,Perez-Berumen C. M,, Estrada-Flores S., (2023) Avances en el desarrollo de nanopartículas transportadores de fármacos para el tratamiento de cáncer, CienciAcierta, 74. http://www.cienciacierta.uadec.mx/articulos/cc74/CC%2374completo.pdf
Bao Y.W., Hua X.W., Li Y.H., Jia H.R., Wu F.G. (2018). Hyperthemia-Promoted Cytosolic and Nuclear Delivery of Copper/Carbon Quantum Dot-crosslinked Nanosheets: Multimodal Imaging-guided Photothermal Cancer Therapy, ACS Appl. Mater. Interfaces 10 (1544e1555)., https://doi.org/10.1021/ acsami.7b15332.
Chuyi H., Xianming Z., Fan W., Qinghua Y., Feng C., Di S., Zhangyou Y., Tingting W., Mingyue J., Tao D., Chao Y. (2021). Duplex Metal Co-Doped Carbon Quantum Dots-Based Drug Delivery System With Intelligent Adjustable Size As Adjuvant For Synergistic Cancer Therapy, Carbon 183 (789-808), https://doi.org/10.1016/j.carbon.2021.07.063.
Daphne E. S. M., Pharm D., B.C.-ADM, CDCES. (2023). University of Illinois at Chicago College of Pharmacy.
Deng T., Wang J., Li Y., Han Z., Peng Y., Zhang J., Gao Z., Gu Y., Deng D. (2018). Quantum Dots-Based Multifunctional Nano-Prodrug Fabricated by Ingenious Self-Assembly Strategies for Tumor Theranostic, ACS Appl. Mater. Interfaces 10 (27657e27668). https://doi.org/10.1021/acsami.8b08512.
Granada-Ramírez D.A., Arias-Cerón J.S., Rodríguez-Fragoso P., Vázquez-Hernández F., Luna-Arias J.P., Herrera-Pérez J.L., Mendoza-Álvarez J.G. Capitulos 16 y 20 (2018) in Quantum dots for biomedical applications, Nanobiomaterials, chapter 16 (411-436), Ed. Roger Narayan, Woodhead publishing, Elsevier. https://doi.org/10.1016/B978-0-08-100716-7.00016-7
Geim K. S., , Morozov A. K., , Jiang S. V., Zhang, D., , Dubonos Y., , Grigorieva S.V, , I. V. Firsov, A. A. (2004) Electric Field Effect In Atomically Thin Carbon Films, Science 306(5696): 666–669, https://doi.org/10.48550/arXiv.cond-mat/0410631.
Gu Z., Zhu S., Yan L., Zhao F., Zhao Y. (2019). Graphene-Based Smart Platforms For Combined Cancer Therapy. Adv Mater 31( 1–27).
Hahm M., Hashim D., Vajtai R., Ajayan P. (2011). A Review: Controlled Synthesis Of Vertically Aligned Carbon Nanotubes. Carbon Lett. 12(185). https://doi.org/10.5714/CL.2011.12.4.185.
Huang X., Mclean R., Zheng M. (2005). High-Resolution Length Sorting And Purification Of DNA-Wrapped Carbon Nanotubes By Size-Exclusion Chromatography. Anal Chem 77(19) 6225-6228. https://doi.org/10.1021/acsnano.3c07668
Hua X.W., Bao Y.W., Chen Z., Wu F.G., (2017). Carbon Quantum Dots With Intrinsic Mitochondrial Targeting Ability for Mitochondria-Based Theranostics, Nanoscale 9 (10948e10960). https://doi.org/10.1039/c7nr03658b.
Irum R., Ayesha K., Zanib A, Bakhtiar M. (2016). Exploration of Epoxy Resins, Hardening Systems, and Epoxy/Carbon Nanotube Composite Designed for High Performance Materials: A Review, Polymer-Plastics Technology and Engineering, 55(3) 312-333. https://doi: 10.1080/03602559.2015.1070874
Juan P. G., Esdras A. Z.-M, Lourdes R.-F. (2022). Chapter, Advances in Graphene Platforms for Drug Delivery in Cancer and Its Biocompatibility. http://dx.doi.org/10.5772/intechopen.103688.
Jashandeep K., Gurlal S. G., Kiran J. (2019). Characterization And Biology Of Nanomaterials For Drug Delivery, chapter 5, Applications of Carbon Nanotubes in Drug Delivery: A Comprehensive Review. https://doi.org/10.1016/B978-0-12-814031-4.00005-2.
Lyra, K.., Kaminari, A., Panagiotaki, K.N., Spyrou, K., Papageorgiou, S., Sakellis, E., Katsaros, F.K., Sideratou, Z. (2021). Multi-Walled Carbon Nanotubes Decorated With Guanidinylated Dendritic Molecular Transporters: An Efficient Platform For The Selective Anticancer Activity Of Doxorubicin, Pharmaceutics. 13(858). https://doi.org/10.3390/pharmaceutics13060858.
Lijima S. (1991). Helical Microtubules of Graphitic Carbon. Nature 354, (6348-56). https://doi: 10.1038/354056a0.
Loera-Serna S, Ruiz-Angeles J, Flores-Moreno J, Soto-Portas L. (2012). Protegiendo fármacos con nanomateriales inteligentes. Mundo Nano. 5. https://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-56912012000100059
Maiti D., Tong X., Mou X., Yang K. (2019) Carbon-based Nanomaterials for Biomedical Applications: a Recent Study. Front Pharmacol, 9,(1–16). https://doi.org/10.3389/fphar.2018.01401
Mahor A., Singh P.P., Bharadwaj P., Sharma N., Yadav S., Rosenholm J.M , Bansal K.K, (2021), Carbon-based nanomaterials for delivery of biologicals and therapeutics: A cutting-edge technology, Journal of Carbon Research,, 7, 19. https://doi.org/10.3390/c7010019
Mohd N. N., Asyraf, M.R.M., Khalina, A., Abdullah, N., Sabaruddin, F.A., Kamarudin, S.H., Ahmad, S., Mahat, A.M., Lee, C.L., Aisyah, H.A. (2021). Fabrication, Functionalization, And Application Of Carbon Nanotube-Reinforced Polymer Composite: An Overview. Polymers 13(1047). https://doi.org/10.3390/polym13071047
Caracuel A. M., (2020) Sistemas de liberación controlada de fármacos obtenidos por impresión 3d. Mecanismos de liberación y factores que influyen, [Tesis de licenciatura, Universidad de Sevilla]. Deposito de investigación Universidad de Sevilla. https://hdl.handle.net/11441/103272
Nayab A., Murtaza N. A., Tooba J. K. (2021). Carbon Quantum Dots For Biomedical Applications: Review And Analysis, Front. Mater. 8 https://doi.org/10.3389/fmats.2021.700403.
PALIWAL S., PANDEY K., PAWAR S., JOSHI H., BISHT N. (2020). A Review On Carbon Nanotubes: As A Nano Carrier Drug Delivery System, Indian J Pharm Sci. 82(5):766-772.
Parand R. R., Roger J. N. (2021). Recent Advances in Carbon Nanomaterials for Biomedical Applications: A Review. Current Opinion in Biomedical Engineering, 17(100262), https://doi.org/10.1016/j.cobme.2021.100262.
Rao C., Govindaraj A., Gundiah G., Vivekchand S. (2004). Nanotubes And Nanowires. Chem Eng Sci. 59(4665). https://doi.org/10.1016/j.ces.2004.07.067.
Rojas-Aguirre Y., Aguado-Castrejón K., González-Méndez I., (2016) La nanomedicina y los sistemas de liberación de fármacos: ¿la revolución de la terapia contra el cáncer?, Educación Química,, 27, 286-291. https://doi.org/10.1016/j.eq.2016.07.002
Rummeli M., Borowiak-Palen E., Gemming T., Pichler T., Knupfer M., Kalbac M., Dunsch L., Jost O., Silva S., PompeW., Buchner B. (2005). Novel Catalysts, Room Temperature, And The Importance Of Oxygen For The Synthesis Of Single-Walled Carbon Nanotubes. Nano Lett 5(7) 1209-1215. https://doi: 10.1021/nl050692v
Shi J., Xiaoyuan Y., Lei W., Yan L., Jun G., Jing Z., Rou M., Ruiyuan L., Zhenzhong Z. (2013). Pegylated Fullerene/Iron Oxide Nanocomposites For Photodynamic Therapy, Targeted Drug Delivery And MR Imaging. Biomaterials 3437(9666-9677). https://doi.org/10.1016/j.biomaterials.2013.08.049
Vander Wal RL, Ticich TM, Curtis VE.(2000). Diffusion Flame Synthesis Of Single-Walled Carbon Nanotubes. Chem Phys Lett. 323(217-223). https://doi.org/10.1016/S0009-2614(00)00522-4.
Vázquez-Hernández F., Granada-Ramírez D.A., Arias-Cerón J.S., Rodriguez-Fragoso P., Mendoza-Álvarez J.G., Ramón-Gallegos E., Cruz-Orea A., Luna-Arias J.P., (2018). Use Of Nanostructured Materials In Drug Delivery, chapter 20, Nanobiomaterials https://doi.org/10.1016/B978-0-08-100716-7.00020-9
Wang Z., Colombi C. L., Wei G. (2017). Recent Advances In The Synthesis Of Graphene-Based Nanomaterials For Controlled Drug Delivery. Applied Sciences. 7(11) 1175. https://doi.org/10.3390/app7111175.
Wu H., Su W., Xu H. (2021). Applications Of Carbon Dots On Tumour Theranostics. VIEW. 2(20200061). https://doi.org/10.1002/VIW.20200061.
Xia Q., Zhang Z., Liu Y., Leng J. (2020). Buckypaper And Its Composites For Aeronautic Applications, Composites Part B: Engineering, 199 (108231). https://doi.org/10.1016/j.compositesb.2020.108231
Yoosefian M., Jahani M. (2019). A Molecular Study On Drug Delivery System Based On Carbon Nanotube For The Novel Norepinephrine Prodrug, Droxidopa. J Mol Liq. 284:258–264. https://doi.org/10.1016/j.molliq.2019.04.016
Zahra S. (2021). Journal of Drug Delivery Science and Technology 66 (102790) https://doi.org/10.1016/j.jddst.2021.102790.
Zhang C., Wu L., de Perrot M., Zhao X. (2021). Carbon Nanotubes: A Summary Of Beneficial And Dangerous Aspects Of An Increasingly Popular Group Of Nanomaterials, Front. Oncol. 11(693814). doi: 10.3389/fonc.2021.693814.
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2024-04-24
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Granada-Ramírez , D. A. ., Panecatl-Bernal, Y. ., Méndez-Rojas, M. A. ., & Alvarado-Pulido, J. J. . (2024). NANOMATERIALES DE CARBONO PARA LIBERACIÓN DE FÁRMACOS. RD-ICUAP, 10(29), 230–240. https://doi.org/10.32399/icuap.rdic.2448-5829.2024.Especial.1355
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