LAS AVES DE GRANJA REQUIEREN VACUNARSE PARA MANTENER LA PRODUCCIÓN DE ALIMENTOS CON ALTO VALOR NUTRICIONAL A BAJO COSTO
DOI:
https://doi.org/10.32399/icuap.rdic.2448-5829.2024.Especial.1346Palabras clave:
Avibacterium paragallinarum, Gallibacterium anatis, coriza infecciosa, vacunas, industria avícola.Resumen
El sector avícola es uno de los más importantes en el mundo y en la sociedad mexicana, gracias a la producción de alimentos de primera necesidad, un ejemplo de esto es que México ocupa los primeros lugares en la exportación de huevo y presenta un consumo per cápita de 22 kilos, posicionándose como el mayor consumidor a nivel mundial. Sin embargo, la industria avícola se ve afectada por infecciones como la coriza infecciosa causada por Avibacterium paragallinarum o la gallibacteriosis cuyo agente causal es Gallibacterium anatis. Estas afectan principalmente a gallinas de postura y pollos de engorde, causando una disminución del 10 al 40% en la producción de huevo, impactando directamente en la salud pública y generando pérdidas económicas relevantes. Lo anterior destaca la importancia en la búsqueda de nuevas alternativas para tener mayor control y prevención de infecciones, donde A. paragallinarum y G. anatis poseen características potenciales para ello.
Citas
Abd El-Ghany, W. A., Algammal, A. M., Hetta, H. F., & Elbestawy, A. R. (2023). Gallibacterium anatis infection in poultry: a comprehensive review. Tropical Animal Health and Production, 55(6), 383. https://doi.org/10.1007/S11250-023-03796-W
Araya-Hidalgo, E., Gutiérrez-Jiménez, C., Chaves-Ramírez, M., Suárez-Esquivel, M., Guzmán-Verri, C., & Barquero-Calvo, E. (2017). Sequence analysis of the hypervariable region in hmtp210 of Avibacterium paragallinarum. The Journal of Veterinary Medical Science, 79(7), 1210. https://doi.org/10.1292/JVMS.16-0530
Bager, R. J., Nesta, B., Pors, S. E., Soriani, M., Serino, L., Boyce, J. D., Adler, B., & Bojesen, A. M. (2013). The Fimbrial Protein FlfA from Gallibacterium anatis Is a Virulence Factor and Vaccine Candidate. Infection and Immunity, 81(6), 1964. https://doi.org/10.1128/IAI.00059-13
Blackall, P. J. (1999). Infectious Coryza: Overview of the Disease and New Diagnostic Options. Clinical Microbiology Reviews, 12(4), 627. https://doi.org/10.1128/CMR.12.4.627
Blackall, P. J., Christensen, H., Beckenham, T., Blackall, L. L., & Bisgaard, M. (2005). Reclassification of Pasteurella gallinarum, [Haemophilus] paragallinarum, Pasteurella avium and Pasteurella volantium as Avibacterium gallinarum gen. nov., comb. nov., Avibacterium paragallinarum comb. nov., Avibacterium avium comb. nov. and Avibacterium volantium comb. nov. International Journal of Systematic and Evolutionary Microbiology, 55(1), 353–362. https://doi.org/10.1099/IJS.0.63357-0/CITE/REFWORKS
Driessche, L. Van, Vanneste, K., Bogaerts, B., de Keersmaecker, S. C. J., Roosens, N. H., Haesebrouck, F., de Cremer, L., Deprez, P., Pardon, B., & Boyen, F. (2020). Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium. Emerging Infectious Diseases, 26(4), 721. https://doi.org/10.3201/EID2604.190962
El huevo mexicano, un alimento muy valioso | Secretaría de Agricultura y Desarrollo Rural | Gobierno | gob.mx. (n.d.). Retrieved December 3, 2023, from https://www.gob.mx/agricultura/articulos/el-huevo-mexicano-un-alimento-muy-valioso.
Falconi-Agapito, F., Saravia, L. E., Flores-Pérez, A., & Fernández-Díaz, M. (2015). Naturally Occurring β-Nicotinamide Adenine Dinucleotide–Independent Avibacterium paragallinarum Isolate in Peru. Https://Doi.Org/10.1637/10969-110314-CaseR, 59(2), 341–343. https://doi.org/10.1637/10969-110314-CASER
García-Gómez, E., Vaca, S., Pérez-Méndez, A., Ibarra-Caballero, J., Pérez-Márquez, V., Tenorio, V. R., & Negrete-Abascal, E. (2005). Gallibacterium anatis-secreted metalloproteases degrade chicken IgG. Avian Pathology, 34(5), 426–429. https://doi.org/10.1080/03079450500267866
Guo, M., Liu, D., Chen, X., Wu, Y., & Zhang, X. (2022). Pathogenicity and innate response to Avibacterium paragallinarum in chickens. Poultry Science, 101(1), 101523. https://doi.org/10.1016/J.PSJ.2021.101523
Jeong, O. M., Kang, M. S., Jeon, B. W., Choi, B. K., Kwon, Y. K., Yoon, S. Y., Blackall, P. J., Lee, H. S., Jung, S. C., & Kim, J. H. (2017). Isolation and characterization of Avibacterium paragallinarum with different nicotinamide adenine dinucleotide requirements. Veterinary Microbiology, 205, 62–65. https://doi.org/10.1016/J.VETMIC.2017.05.005
Kristensen, B. M., Frees, D., & Bojesen, A. M. (2010). GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation. Veterinary Research, 41(3), 25. https://doi.org/10.1051/VETRES/2009073
Lieberman, L. A. (2022). Outer membrane vesicles: A bacterial-derived vaccination system. Frontiers in Microbiology, 13, 1029146. https://doi.org/10.3389/FMICB.2022.1029146/BIBTEX
Liu, C. C., Ou, S. C., Tan, D. H., Hsieh, M. K., Shien, J. H., & Chang, P. C. (2016). The Fimbrial Protein is a Virulence Factor and Potential Vaccine Antigen of Avibacterium paragallinarum. Https://Doi.Org/10.1637/11410-031316-Reg.1, 60(3), 649–655. https://doi.org/10.1637/11410-031316-REG.1
Luna-Castrejón, L. P., Buter, R., Pantoja-Nuñez, G. I., Acuña-Yanes, M., Ceballos-Valenzuela, K., Talavera-Rojas, M., Salgado-Miranda, C., Heuvelink, A., De Wit, S., Soriano-Vargas, E., & Feberwee, A. (2020). Identification, HPG2 Sequence Analysis, and Antimicrobial Susceptibility of Avibacterium paragallinarum Isolates Obtained from Outbreaks of Infectious Coryza in Commercial Layers in Sonora State, Mexico. Https://Doi.Org/10.1637/Aviandiseases-D-20-00103, 65(1), 95–101. https://doi.org/10.1637/AVIANDISEASES-D-20-00103
Mei, C., Sun, A. H., Blackall, P. J., Xian, H., Li, S. F., Gong, Y. M., & Wang, H. J. (2020). Component Identification and Functional Analysis of Outer Membrane Vesicles Released by Avibacterium paragallinarum. Frontiers in Microbiology, 11, 518060. https://doi.org/10.3389/FMICB.2020.518060/BIBTEX
Montes-García, J. F., Vaca, S., Vazquez-Cruz, C., Soriano-Vargas, E., Aguilar-Romero, F., Blackall, P. J., & Negrete-Abascal, E. (2016). Identification of a Hemagglutinin from Gallibacterium anatis. Current Microbiology, 72(4), 450–456. https://doi.org/10.1007/S00284-015-0969-5/FIGURES/5
Morales-Erasto, V., Fernández-Rosas, P., Negrete-Abascal, E., Salazar-García, F., Blackall, P. J., & Soriano-Vargas, E. (2013). Genotyping, Pathogenicity, and Immunogenicity of Avibacterium paragallinarum Serovar B-1 Isolates from the Americas. Https://Doi.Org/10.1637/10693-101513-ResNote.1, 58(2), 293–296. https://doi.org/10.1637/10693-101513-RESNOTE.1
Narasinakuppe Krishnegowda, D., Dhama, K., Kumar Mariappan, A., Munuswamy, P., Iqbal Yatoo, M., Tiwari, R., Karthik, K., Bhatt, P., & Reddy, M. R. (2020). Etiology, epidemiology, pathology, and advances in diagnosis, vaccine development, and treatment of Gallibacterium anatis infection in poultry: a review. The Veterinary Quarterly, 40(1), 16. https://doi.org/10.1080/01652176.2020.1712495
Pan, Y. C., Tan, D. H., Shien, J. H., Liu, C. C., He, Y. S., Shen, P. C., & Chang, P. C. (2012). Identification and Characterization of an RTX Toxin–Like Gene and Its Operon from Avibacterium paragallinarum. Https://Doi.Org/10.1637/10047-122211-Reg.1, 56(3), 537–544. https://doi.org/10.1637/10047-122211-REG.1
Paudel, S., Hess, M., & Hess, C. (2016). Coinfection of Avibacterium paragallinarum and Gallibacterium anatis in Specific-Pathogen-Free Chickens Complicates Clinical Signs of Infectious Coryza, Which Can Be Prevented by Vaccination. Https://Doi.Org/10.1637/11481-081016-Reg, 61(1), 55–63. https://doi.org/10.1637/11481-081016-REG
Persson, G., & Bojesen, A. M. (2015). Bacterial determinants of importance in the virulence of Gallibacterium anatis in poultry. Veterinary Research, 46(1), 1–11. https://doi.org/10.1186/S13567-015-0206-Z/FIGURES/5
Ramón Rocha, M. O., García-González, O., Pérez-Méndez, A., Ibarra-Caballero, J., Pérez-Márquez, V. M., Vaca, S., & Negrete-Abascal, E. (2006). Membrane vesicles released by Avibacterium paragallinarum contain putative virulence factors. FEMS Microbiology Letters, 257(1), 63–68. https://doi.org/10.1111/J.1574-6968.2006.00154.X
Sanchez-Alonso, P., Cobos-Justo, E., Avalos-Rangel, M. A., López-Reyes, L., Paniagua-Contreras, G. L., Vaca-Paniagua, F., Anastacio-Marcelino, E., López-Ochoa, A. J., Pérez Marquez, V. M., Negrete-Abascal, E., & Vázquez-Cruz, C. (2023). A Maverick-like cluster in the genome of a pathogenic, moderately virulent strain of Gallibacterium anatis, ESV200, a transient biofilm producer. Frontiers in Microbiology, 14, 1084766. https://doi.org/10.3389/FMICB.2023.1084766/BIBTEX
Soriano-Vargas, E., Sánchez-Morales, J., Morales-Erasto, V., & García-Sánchez, A. (2013). Aislamiento e identificación de Avibacterium paragallinarum NAD independiente (serovariedad C-1) en gallinas de reemplazo con coriza infecciosa. Veterinaria México, 44(1), 57–62. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0301-50922013000100005&lng=es&nrm=iso&tlng=es
Tang, B., Pors, S. E., Kristensen, B. M., Skjerning, R. B. J., Olsen, R. H., & Bojesen, A. M. (2020). GtxA is a virulence factor that promotes a Th2-like response during Gallibacterium anatis infection in laying hens. Veterinary Research, 51(1), 1–12. https://doi.org/10.1186/S13567-020-00764-2/FIGURES/7
Tu, T. Y., Hsieh, M. K., Tan, D. H., Ou, S. C., Shien, J. H., Yen, T. Y., & Chang, P. C. (2014). Loss of the Capsule Increases the Adherence Activity, but Decreases the Virulence of Avibacterium paragallinarum. Https://Doi.Org/10.1637/10937-091414-Reg, 59(1), 87–93. https://doi.org/10.1637/10937-091414-REG
Wang, Y. P., Hsieh, M. K., Tan, D. H., Shien, J. H., Ou, S. C., Chen, C. F., & Chang, P. C. (2014). The haemagglutinin of Avibacterium paragallinarum is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. Veterinary Microbiology, 174(3–4), 474–482. https://doi.org/10.1016/J.VETMIC.2014.10.013
Wu, J. R., Chen, P. Y., Shien, J. H., Shyu, C. L., Shieh, H. K., Chang, F., & Chang, P. C. (2010). Analysis of the biosynthesis genes and chemical components of the capsule of Avibacterium paragallinarum. Veterinary Microbiology, 145(1–2), 90–99. https://doi.org/10.1016/J.VETMIC.2010.03.002
Xu, Y., Cheng, J., Huang, X., Xu, M., Feng, J., Liu, C., & Zhang, G. (2019). Characterization of emergent Avibacterium paragallinarum strains and the protection conferred by infectious coryza vaccines against them in China. Poultry Science, 98(12), 6463–6471. https://doi.org/10.3382/PS/PEZ531
Araya-Hidalgo, E., Gutiérrez-Jiménez, C., Chaves-Ramírez, M., Suárez-Esquivel, M., Guzmán-Verri, C., & Barquero-Calvo, E. (2017). Sequence analysis of the hypervariable region in hmtp210 of Avibacterium paragallinarum. The Journal of Veterinary Medical Science, 79(7), 1210. https://doi.org/10.1292/JVMS.16-0530
Bager, R. J., Nesta, B., Pors, S. E., Soriani, M., Serino, L., Boyce, J. D., Adler, B., & Bojesen, A. M. (2013). The Fimbrial Protein FlfA from Gallibacterium anatis Is a Virulence Factor and Vaccine Candidate. Infection and Immunity, 81(6), 1964. https://doi.org/10.1128/IAI.00059-13
Blackall, P. J. (1999). Infectious Coryza: Overview of the Disease and New Diagnostic Options. Clinical Microbiology Reviews, 12(4), 627. https://doi.org/10.1128/CMR.12.4.627
Blackall, P. J., Christensen, H., Beckenham, T., Blackall, L. L., & Bisgaard, M. (2005). Reclassification of Pasteurella gallinarum, [Haemophilus] paragallinarum, Pasteurella avium and Pasteurella volantium as Avibacterium gallinarum gen. nov., comb. nov., Avibacterium paragallinarum comb. nov., Avibacterium avium comb. nov. and Avibacterium volantium comb. nov. International Journal of Systematic and Evolutionary Microbiology, 55(1), 353–362. https://doi.org/10.1099/IJS.0.63357-0/CITE/REFWORKS
Driessche, L. Van, Vanneste, K., Bogaerts, B., de Keersmaecker, S. C. J., Roosens, N. H., Haesebrouck, F., de Cremer, L., Deprez, P., Pardon, B., & Boyen, F. (2020). Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium. Emerging Infectious Diseases, 26(4), 721. https://doi.org/10.3201/EID2604.190962
El huevo mexicano, un alimento muy valioso | Secretaría de Agricultura y Desarrollo Rural | Gobierno | gob.mx. (n.d.). Retrieved December 3, 2023, from https://www.gob.mx/agricultura/articulos/el-huevo-mexicano-un-alimento-muy-valioso.
Falconi-Agapito, F., Saravia, L. E., Flores-Pérez, A., & Fernández-Díaz, M. (2015). Naturally Occurring β-Nicotinamide Adenine Dinucleotide–Independent Avibacterium paragallinarum Isolate in Peru. Https://Doi.Org/10.1637/10969-110314-CaseR, 59(2), 341–343. https://doi.org/10.1637/10969-110314-CASER
García-Gómez, E., Vaca, S., Pérez-Méndez, A., Ibarra-Caballero, J., Pérez-Márquez, V., Tenorio, V. R., & Negrete-Abascal, E. (2005). Gallibacterium anatis-secreted metalloproteases degrade chicken IgG. Avian Pathology, 34(5), 426–429. https://doi.org/10.1080/03079450500267866
Guo, M., Liu, D., Chen, X., Wu, Y., & Zhang, X. (2022). Pathogenicity and innate response to Avibacterium paragallinarum in chickens. Poultry Science, 101(1), 101523. https://doi.org/10.1016/J.PSJ.2021.101523
Jeong, O. M., Kang, M. S., Jeon, B. W., Choi, B. K., Kwon, Y. K., Yoon, S. Y., Blackall, P. J., Lee, H. S., Jung, S. C., & Kim, J. H. (2017). Isolation and characterization of Avibacterium paragallinarum with different nicotinamide adenine dinucleotide requirements. Veterinary Microbiology, 205, 62–65. https://doi.org/10.1016/J.VETMIC.2017.05.005
Kristensen, B. M., Frees, D., & Bojesen, A. M. (2010). GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation. Veterinary Research, 41(3), 25. https://doi.org/10.1051/VETRES/2009073
Lieberman, L. A. (2022). Outer membrane vesicles: A bacterial-derived vaccination system. Frontiers in Microbiology, 13, 1029146. https://doi.org/10.3389/FMICB.2022.1029146/BIBTEX
Liu, C. C., Ou, S. C., Tan, D. H., Hsieh, M. K., Shien, J. H., & Chang, P. C. (2016). The Fimbrial Protein is a Virulence Factor and Potential Vaccine Antigen of Avibacterium paragallinarum. Https://Doi.Org/10.1637/11410-031316-Reg.1, 60(3), 649–655. https://doi.org/10.1637/11410-031316-REG.1
Luna-Castrejón, L. P., Buter, R., Pantoja-Nuñez, G. I., Acuña-Yanes, M., Ceballos-Valenzuela, K., Talavera-Rojas, M., Salgado-Miranda, C., Heuvelink, A., De Wit, S., Soriano-Vargas, E., & Feberwee, A. (2020). Identification, HPG2 Sequence Analysis, and Antimicrobial Susceptibility of Avibacterium paragallinarum Isolates Obtained from Outbreaks of Infectious Coryza in Commercial Layers in Sonora State, Mexico. Https://Doi.Org/10.1637/Aviandiseases-D-20-00103, 65(1), 95–101. https://doi.org/10.1637/AVIANDISEASES-D-20-00103
Mei, C., Sun, A. H., Blackall, P. J., Xian, H., Li, S. F., Gong, Y. M., & Wang, H. J. (2020). Component Identification and Functional Analysis of Outer Membrane Vesicles Released by Avibacterium paragallinarum. Frontiers in Microbiology, 11, 518060. https://doi.org/10.3389/FMICB.2020.518060/BIBTEX
Montes-García, J. F., Vaca, S., Vazquez-Cruz, C., Soriano-Vargas, E., Aguilar-Romero, F., Blackall, P. J., & Negrete-Abascal, E. (2016). Identification of a Hemagglutinin from Gallibacterium anatis. Current Microbiology, 72(4), 450–456. https://doi.org/10.1007/S00284-015-0969-5/FIGURES/5
Morales-Erasto, V., Fernández-Rosas, P., Negrete-Abascal, E., Salazar-García, F., Blackall, P. J., & Soriano-Vargas, E. (2013). Genotyping, Pathogenicity, and Immunogenicity of Avibacterium paragallinarum Serovar B-1 Isolates from the Americas. Https://Doi.Org/10.1637/10693-101513-ResNote.1, 58(2), 293–296. https://doi.org/10.1637/10693-101513-RESNOTE.1
Narasinakuppe Krishnegowda, D., Dhama, K., Kumar Mariappan, A., Munuswamy, P., Iqbal Yatoo, M., Tiwari, R., Karthik, K., Bhatt, P., & Reddy, M. R. (2020). Etiology, epidemiology, pathology, and advances in diagnosis, vaccine development, and treatment of Gallibacterium anatis infection in poultry: a review. The Veterinary Quarterly, 40(1), 16. https://doi.org/10.1080/01652176.2020.1712495
Pan, Y. C., Tan, D. H., Shien, J. H., Liu, C. C., He, Y. S., Shen, P. C., & Chang, P. C. (2012). Identification and Characterization of an RTX Toxin–Like Gene and Its Operon from Avibacterium paragallinarum. Https://Doi.Org/10.1637/10047-122211-Reg.1, 56(3), 537–544. https://doi.org/10.1637/10047-122211-REG.1
Paudel, S., Hess, M., & Hess, C. (2016). Coinfection of Avibacterium paragallinarum and Gallibacterium anatis in Specific-Pathogen-Free Chickens Complicates Clinical Signs of Infectious Coryza, Which Can Be Prevented by Vaccination. Https://Doi.Org/10.1637/11481-081016-Reg, 61(1), 55–63. https://doi.org/10.1637/11481-081016-REG
Persson, G., & Bojesen, A. M. (2015). Bacterial determinants of importance in the virulence of Gallibacterium anatis in poultry. Veterinary Research, 46(1), 1–11. https://doi.org/10.1186/S13567-015-0206-Z/FIGURES/5
Ramón Rocha, M. O., García-González, O., Pérez-Méndez, A., Ibarra-Caballero, J., Pérez-Márquez, V. M., Vaca, S., & Negrete-Abascal, E. (2006). Membrane vesicles released by Avibacterium paragallinarum contain putative virulence factors. FEMS Microbiology Letters, 257(1), 63–68. https://doi.org/10.1111/J.1574-6968.2006.00154.X
Sanchez-Alonso, P., Cobos-Justo, E., Avalos-Rangel, M. A., López-Reyes, L., Paniagua-Contreras, G. L., Vaca-Paniagua, F., Anastacio-Marcelino, E., López-Ochoa, A. J., Pérez Marquez, V. M., Negrete-Abascal, E., & Vázquez-Cruz, C. (2023). A Maverick-like cluster in the genome of a pathogenic, moderately virulent strain of Gallibacterium anatis, ESV200, a transient biofilm producer. Frontiers in Microbiology, 14, 1084766. https://doi.org/10.3389/FMICB.2023.1084766/BIBTEX
Soriano-Vargas, E., Sánchez-Morales, J., Morales-Erasto, V., & García-Sánchez, A. (2013). Aislamiento e identificación de Avibacterium paragallinarum NAD independiente (serovariedad C-1) en gallinas de reemplazo con coriza infecciosa. Veterinaria México, 44(1), 57–62. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0301-50922013000100005&lng=es&nrm=iso&tlng=es
Tang, B., Pors, S. E., Kristensen, B. M., Skjerning, R. B. J., Olsen, R. H., & Bojesen, A. M. (2020). GtxA is a virulence factor that promotes a Th2-like response during Gallibacterium anatis infection in laying hens. Veterinary Research, 51(1), 1–12. https://doi.org/10.1186/S13567-020-00764-2/FIGURES/7
Tu, T. Y., Hsieh, M. K., Tan, D. H., Ou, S. C., Shien, J. H., Yen, T. Y., & Chang, P. C. (2014). Loss of the Capsule Increases the Adherence Activity, but Decreases the Virulence of Avibacterium paragallinarum. Https://Doi.Org/10.1637/10937-091414-Reg, 59(1), 87–93. https://doi.org/10.1637/10937-091414-REG
Wang, Y. P., Hsieh, M. K., Tan, D. H., Shien, J. H., Ou, S. C., Chen, C. F., & Chang, P. C. (2014). The haemagglutinin of Avibacterium paragallinarum is a trimeric autotransporter adhesin that confers haemagglutination, cell adherence and biofilm formation activities. Veterinary Microbiology, 174(3–4), 474–482. https://doi.org/10.1016/J.VETMIC.2014.10.013
Wu, J. R., Chen, P. Y., Shien, J. H., Shyu, C. L., Shieh, H. K., Chang, F., & Chang, P. C. (2010). Analysis of the biosynthesis genes and chemical components of the capsule of Avibacterium paragallinarum. Veterinary Microbiology, 145(1–2), 90–99. https://doi.org/10.1016/J.VETMIC.2010.03.002
Xu, Y., Cheng, J., Huang, X., Xu, M., Feng, J., Liu, C., & Zhang, G. (2019). Characterization of emergent Avibacterium paragallinarum strains and the protection conferred by infectious coryza vaccines against them in China. Poultry Science, 98(12), 6463–6471. https://doi.org/10.3382/PS/PEZ531
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2024-04-24
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Matias Vera, S. A. ., Sánchez Alonso, M. P. ., Negrete Abascal, E. ., & Vázquez Cruz, C. . (2024). LAS AVES DE GRANJA REQUIEREN VACUNARSE PARA MANTENER LA PRODUCCIÓN DE ALIMENTOS CON ALTO VALOR NUTRICIONAL A BAJO COSTO. RD-ICUAP, 10(29), 150–163. https://doi.org/10.32399/icuap.rdic.2448-5829.2024.Especial.1346
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