BACTERIAS MULTIDROGORESISTENTES ¿LA PANDEMIA QUE VIENE?
DOI:
https://doi.org/10.32399/icuap.rdic.2448-5829.2024.10.28.1233Palabras clave:
Bacterias multidrogoresistentes, resistencia a los antimicrobianos, ESKAPEResumen
La recién cursada pandemia ocasionada por el virus SARS-CoV2, nos ha dejado varias lecciones; dentro de ellas destaca la vulnerabilidad del ser humano como especie al daño que pueden causar agentes infecciosos, pero también que con la participación responsable de la sociedad en conjunto con las políticas públicas se pueden contener los embates de esas fuerzas de la evolución. Un enemigo silencioso que ha estado al acecho y que crece constantemente lo constituyen las bacterias, que por su plasticidad tienen una alta capacidad de adquirir y desarrollar mecanismos para evadir la acción de los fármacos que utilizamos para el control de las infecciones. En este documento, se presenta el estado actual de los principales agentes microbianos causantes de infecciones y que han sido catalogados como prioritarios para agencias de salud internacionales y el panorama que representa que alberguen mecanismos de resistencia para su contención. De igual forma, se mencionan aspectos regulatorios y el papel de la sociedad para evitar la diseminación de bacterias Multidrogorresistentes.
Citas
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Chang, C. Y., Huang, P. H., & Lu, P. L. (2022). The Resistance Mechanisms and Clinical Impact of Resistance to the Third Generation Cephalosporins in Species of Enterobacter cloacae Complex in Taiwan. Antibiotics, 11(9). https://doi.org/10.3390/antibiotics11091153
Companyó, R., Granados, M., Guiteras, J., & Prat, M. D. (2009). Antibiotics in food: Legislation and validation of analytical methodologies. Analytical and Bioanalytical Chemistry, 395(4), 877–891. https://doi.org/10.1007/s00216-009-2969-4
Deng, Y., Bao, X., Ji, L., Chen, L., Liu, J., Miao, J., Chen, D., Bian, H., Li, Y., & Yu, G. (2015). Resistance integrons: class 1, 2 and 3 integrons. Annals of Clinical Microbiology and Antimicrobials, 14, 45. https://doi.org/10.1186/s12941-015-0100-6
Denissen, J., Reyneke, B., Waso-Reyneke, M., Havenga, B., Barnard, T., Khan, S., & Khan, W. (2022). Prevalence of ESKAPE pathogens in the environment: Antibiotic resistance status, community-acquired infection and risk to human health. International Journal of Hygiene and Environmental Health, 244. https://doi.org/10.1016/j.ijheh.2022.114006
Díaz-Jiménez, D., García-Meniño, I., Fernández, J., García, V., & Mora, A. (2020). Chicken and turkey meat: Consumer exposure to multidrug-resistant Enterobacteriaceae including mcr-carriers, uropathogenic E. coli and high-risk lineages such as ST131. International Journal of Food Microbiology, 331. https://doi.org/10.1016/j.ijfoodmicro.2020.108750
Dreser, A., Vázquez-Vélez, E., Treviño, S., & Wirtz, V. J. (2012). Regulation of antibiotic sales in Mexico: an analysis of printed media coverage and stakeholder participation. BMC Public Health, 12, 1051. https://doi.org/10.1186/1471-2458-12-1051
Fleece, M. E., Pholwat, S., Mathers, A. J., & Houpt, E. R. (2018). Molecular diagnosis of antimicrobial resistance in Escherichia coli. Expert Review of Molecular Diagnostics, 18(3), 207–217. https://doi.org/10.1080/14737159.2018.1439381
Flores Morales, C., Rocha Gracia, R. del C., Barrios Villa, E., Lozano Zarain, P., & Cortés Cortés, G. (2023). Staphylococcus aureus y Escherichia coli: dos Bacterias Multidrogorresistentes que Podemos Compartir con Nuestras Mascotas. INVURNUS, 17(1). https://doi.org/10.46588/invurnus.v17i1.98
Gupta, N., Angadi, K., & Jadhav, S. (2022). Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review. In Infection and Drug Resistance (Vol. 15, pp. 7631–7650). Dove Medical Press Ltd. https://doi.org/10.2147/IDR.S386641
Han, Y. L., Wen, X. H., Zhao, W., Cao, X. S., Wen, J. X., Wang, J. R., Hu, Z. De, & Zheng, W. Q. (2022). Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.1003783
Harmer, C. J., & Hall, R. M. (2016). IS26-Mediated Formation of Transposons Carrying Antibiotic Resistance Genes. MSphere, 1(2), 1–8. https://doi.org/10.1128/mSphere.00038-16.Editor
Iovleva, A., Mustapha, M. M., Griffith, M. P., Komarow, L., Luterbach, C., Evans, D. R., Cober, E., Richter, S. S., Rydell, K., Arias, C. A., Jacob, J. T., Salata, R. A., Satlin, M. J., Wong, D., Bonomo, R. A., Van Duin, D., Cooper, V. S., Van Tyne, D., & Doi, Y. (2022). Carbapenem-Resistant Acinetobacter baumannii in U.S. Hospitals: Diversification of Circulating Lineages and Antimicrobial Resistance. MBio, 13(2). https://doi.org/10.1128/mbio.02759-21
Jiang, Y., Ding, Y., Wei, Y., Jian, C., Liu, J., & Zeng, Z. (2022). Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.1045206
Laborda, P., Martínez, J. L., & Hernando-Amado, S. (2022). Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa. Microbiology Spectrum, 10(4). https://doi.org/10.1128/spectrum.00247-22
Lakhundi, S., & Zhang, K. (2018). Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology. Clinical Microbiology Reviews, 31(4). https://doi.org/10.1128/CMR.00020-18
Lebreton, F., van Schaik, W., McGuire, A. M., Godfrey, P., Griggs, A., Mazumdar, V., Corander, J., Cheng, L., Saif, S., Young, S., Zeng, Q., Wortman, J., Birren, B., Willems, R. J. L., Earl, A. M., & Gilmore, M. S. (2013). Emergence of epidemic multidrug-resistant Enterococcus faecium from animal and commensal strains. MBio. https://doi.org/10.1128/mBio.00534-13
Lee, A. S., De Lencastre, H., Garau, J., Kluytmans, J., Malhotra-Kumar, S., Peschel, A., & Harbarth, S. (2018). Methicillin-resistant Staphylococcus aureus. Nature Reviews Disease Primers, 4. https://doi.org/10.1038/nrdp.2018.33
Loeb, J. (2021a). Prescribing breaches are getting political. Veterinary Record, March-April, 203–203. https://doi.org/10.1002/vetr.310
Loeb, J. (2021b). Responsible use is not zero use. Veterinary Record, July, 49–49. https://doi.org/10.1002/vetr.732
Madden, D. E., McCarthy, K. L., Bell, S. C., Olagoke, O., Baird, T., Neill, J., Ramsay, K. A., Kidd, T. J., Stewart, A. G., Subedi, S., Choong, K., Fraser, T. A., Sarovich, D. S., & Price, E. P. (2022). Rapid fluoroquinolone resistance detection in Pseudomonas aeruginosa using mismatch amplification mutation assay-based real-time PCR. Journal of Medical Microbiology, 71(10). https://doi.org/10.1099/jmm.0.001593
Marturano, J. E., & Lowery, T. J. (2019). ESKAPE pathogens in bloodstream infections are associated with higher cost and mortality but can be predicted using diagnoses upon admission. Open Forum Infectious Diseases, 6(12). https://doi.org/10.1093/ofid/ofz503
Mazel, D. (2006). Integrons: Agents of bacterial evolution. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro1462
Mende, K., Akers, K. S., Tyner, S. D., Bennett, J. W., Simons, M. P., Blyth, D. M., Li, P., Stewart, L., & Tribble, D. R. (2022a). Multidrug-Resistant and Virulent Organisms Trauma Infections: Trauma Infectious Disease Outcomes Study Initiative. Military Medicine, 187, 42–51. https://doi.org/10.1093/milmed/usab131
Méndez-Moreno, E., Caporal-Hernandez, L., Mendez-Pfeiffer, P. A., Enciso-Martinez, Y., De la Rosa López, R., Valencia, D., Arenas-Hernández, M. M. P., Ballesteros-Monrreal, M. G., & Barrios-Villa, E. (2022). Characterization of Diarreaghenic Escherichia coli Strains Isolated from Healthy Donors, including a Triple Hybrid Strain. Antibiotics, 11(7). https://doi.org/10.3390/antibiotics11070833
Mills, J. P., & Marchaim, D. (2021). Multidrug-Resistant Gram-Negative Bacteria: Infection Prevention and Control Update. Infectious Disease Clinics of North America, 35(4), 969–994. https://doi.org/10.1016/j.idc.2021.08.001
Mlynarczyk-Bonikowska, B., Kowalewski, C., Krolak-Ulinska, A., & Marusza, W. (2022). Molecular Mechanisms of Drug Resistance in Staphylococcus aureus. International Journal of Molecular Sciences, 23(15). https://doi.org/10.3390/ijms23158088
Mota-Bravo, L., Camps, M., Muñoz-Gutiérrez, I., Tatarenkov, A., Warner, C., Suarez, I., & Cortés-Cortés, G. (2023). Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli. Journal of Visualized Experiments : JoVE, 193. https://doi.org/10.3791/64523
Nucleo, E., Caltagirone, M., Marchetti, V. M., D’Angelo, R., Fogato, E., Confalonieri, M., Reboli, C., March, A., Sleghel, F., Soelva, G., Pagani, E., Aschbacher, R., Migliavacca, R., Pagani, L., Farina, C., Fazii, P., Luzzaro, F., & Montanera, P. G. (2018a). Colonization of long-term care facility residents in three Italian Provinces by multidrug-resistant bacteria. Antimicrobial Resistance and Infection Control, 7(1). https://doi.org/10.1186/s13756-018-0326-0
Pendleton, J. N., Gorman, S. P., & Gilmore, B. F. (2013). Clinical relevance of the ESKAPE pathogens. Expert Review of Anti-Infective Therapy, 11(3), 297–308. https://doi.org/10.1586/eri.13.12
Pérez-Etayo, L., Berzosa, M., González, D., & Vitas, A. I. (2018). Prevalence of integrons and insertion sequences in esbl-producing E. coli isolated from different sources in Navarra, Spain. International Journal of Environmental Research and Public Health, 15(10). https://doi.org/10.3390/ijerph15102308
Qin, S., Xiao, W., Zhou, C., Pu, Q., Deng, X., Lan, L., Liang, H., Song, X., & Wu, M. (2022). Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduction and Targeted Therapy, 7(1). https://doi.org/10.1038/s41392-022-01056-1
Ríos Ruy-Pérez, C. (2004). Legislación sobre Antibióticos en América Latina. In Oficina Sanitaria Panamericana, OPS. https://www3.paho.org/spanish/ad/dpc/cd/amr-legis.pdf
Rowe-Magnus, D. A., & Mazel, D. (2001). Integrons: Natural tools for bacterial genome evolution. Current Opinion in Microbiology. https://doi.org/10.1016/S1369-5274(00)00252-6
Ruekit, S., Srijan, A., Serichantalergs, O., Margulieux, K. R., Mc Gann, P., Mills, E. G., Stribling, W. C., Pimsawat, T., Kormanee, R., Nakornchai, S., Sakdinava, C., Sukhchat, P., Wojnarski, M., Demons, S. T., Crawford, J. M., Lertsethtakarn, P., & Swierczewski, B. E. (2022). Molecular characterization of multidrug-resistant ESKAPEE pathogens from clinical samples in Chonburi, Thailand (2017–2018). BMC Infectious Diseases, 22(1). https://doi.org/10.1186/s12879-022-07678-8
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2024-01-07
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Barrios-Villa, E. . (2024). BACTERIAS MULTIDROGORESISTENTES ¿LA PANDEMIA QUE VIENE?. RD-ICUAP, 10(28), 9–21. https://doi.org/10.32399/icuap.rdic.2448-5829.2024.10.28.1233
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