Hormonas Esteroideas Sexuales: Moléculas Moderadoras de la Infección Bacteriana
DOI:
https://doi.org/10.32399/icuap.rdic.2448-5829.2023.26.1080Resumen
El desarrollo de cualquier organismo es un evento jerárquico y secuencial que ocurre a través de la comunicación celular. Estos procesos de comunicación en eucariontes se llevan a cabo por medio de moléculas diversas, incluidas las hormonas. Las hormonas esteroideas participan en el desarrollo de los vertebrados, para controlar los rasgos distintivos de género, y que con ello pueda ocurrir la reproducción. Los andrógenos, estrógenos y progestágenos son fundamentales en el desarrollo del nuevo ser vivo, porque marcan a las diferentes células, de la madre gestante y del producto. Estas hormonas al ser mensajeros de flujos metabólicos son percibidas por los receptores celulares del vertebrado en desarrollo, aunque también pueden ser detectadas por algunos microorganismos circundantes que forman parte del microbioma. Así, estos microorganismos reconocen: i) el momento de desarrollo del hospedero, ii) el vigor o la debilidad del hospedador y iii) los sistemas de defensa contra las infecciones incluyendo la formación de biopelícula. La comunidad microbiana percibe la fortaleza del sistema inmune, por medio de la concentración de hormonas, y se mantiene contenida en las biopelículas o se dispersa a otros tejidos al detectar un sistema inmune débil, dañando al hospedero. Los cambios en la concentración de hormonas también provocan cambios en concentraciones de moléculas como glucosa y aminoácidos, que modifican el crecimiento microbiano, dificultando más el control de una infección. Comprender la importancia de las hormonas en la susceptibilidad a las infecciones es intrincado y desafiante; en este texto se muestra un panorama del tema.
Citas
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Edwards, D. P. (2005). Regulation of signal transduction pathways by estrogen and progesterone. Annual Review of Physiology. 67:335–376.
Feraco, D., Blaha, M., Khan, S., Green, J. M., y Plotkin B.J. (2016). Host environmental signals and effects on biofilm formation. Microbial Pathogenesis 99:253-263.
García-Gómez, E., González-Pedrajo, B. y Camacho-Arroyo, I. (2013). Role of sex steroid hormones in bacterial-host interactions. BioMed Research International. 3:928-238.
Giannoni, E., Guignard, L., Reymond, M. K., Perreau, M., Roth-Kleiner, M., Calandra, T. y Roger, T. (2011). Estradiol and progesterone strongly inhibit the innate immune response of mononuclear cells in newborns. Infection and Immunity. 79:7.
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Gómez-Chang, E., Larrea, F. y Martínez-Montes, F. (2012). Vías de señalización asociadas a la esteroidogénesis. Revista Especializada en Ciencias Químico-Biológicas. 15(1): 24-36.
Hafner, L. M., Cunningham, K. y Beagley, K. W. (2013). Ovarian steroid hormones: effects on immune responses and Chlamydia trachomatis infections of the female genital tract. Mucosal Immunology. 6:859-875.
Hilton, H., Clarke, C. y Graham, J. (2018). Estrogen and progesterone signaling in the normal breast and implications for cancer development. Molecular and Cellular Endocrinology. 466:2-14.
Ho, C.-H., Lu, Y.-C., Fan, C.-K., Yu, H.-J., Liu, H.-T., Wu, C.-C., Chen, K.-C., Liu, S.-P. y Cheng, P.-C. (2020). Testosterone regulates the intracellular bacterial community formation of uropathogenic Escherichia coli in prostate cells via STAT3. International Journal of Medical Microbiology. 310(7):151.
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Kita, E., Takahashi, S., Yasui. K. y Kashiba, S. (1985). Effect of estrogen (17-beta-estradiol) on the susceptibility of mice to disseminated gonococcal infection. Infection and Immunity. 49:238-243.
Klein, S. L. (2000). The effects of hormones on sex differences in infection: from genes to behavior. Neuroscience and Biobehavioral Reviews, 24(6): 627–638.
Komesaroff, P. A., Black, C. V., Cable V. y Sudhir, K. (2001). Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 4(2):144-50.
Kuo, T., McQueen, A., Chen, T. C. y Wang, J. C. (2015). Regulation of Glucose Homeostasis by Glucocorticoids. Advances in Experimental Medicine and Biology. 872: 99–126.
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Leite, L. C. G., Dos Santos, M. C., Duarte, N. E., Horimoto, A. R. V. R., Crispim, F., Vieira Filho, J. P. B., Dal Fabbro, A. L., Franco, L. J., & Moises, R. S. (2022). Association of fat mass and obesity-associated (FTO) gene rs9939609 with obesity-related traits and glucose intolerance in an indigenous population, the Xavante. Diabetes & metabolic syndrome, 16(1), 102358.
Li, J., Lai, H., Chen, S., Zhu, H. y Lai, S. (2017). Interaction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men: The Third National Health and Nutrition Examination Survey. Journal of Diabetes and its Complications, 31(2):318–327.
Loria, R. M. (2009). Beta - Androstenes and resistance to viral and bacterial infections. Neuroimmunomodulation.16:88-95.
Luconi, M., Bonaccorsi, L., Maggi, M., Pecchioli, P., Krausz, C., Forti, G. y Baldi, E. (1998). Identification and characterization of functional non-genomic progesterone receptors on human sperm membrane. Journal Clinical of Endocrinology. 83(3):877-885.
Montes-García, J. F., Chincoya, D., Vaca, S., Vázquez, C., Sánchez, P., Cortes, J., Trujillo-Ruiz, H. y Negrete-Abascal, E. (2018). Identification of two adhesins of Actinobacillus seminis. Small Ruminant Research. 167:100–103.
Montes-García, J.F., Delgado-Tapia, W.A., Vaca, S., Negrete-Abascal, E., Vazquez-Cruz, C. y Cruz-Córdova, A. (2019). Actinobacillus seminis GroEL-homologous protein agglutinates sheep erythrocytes. Antonie van Leeuwenhoek. 112:1655-1662.
Montes-García, J. F., Paniagua-Contreras, G. L., Uribe-García, A., Vaca-Pacheco, S., Vazquez-Cruz, C. y Negrete-Abascal, E. (2017). Bacterias de la familia Pasteurellaceae como modelo de estudios de la biopelícula. En Modelos microbianos para la investigación básica y la Biotecnología. pp. 19-34. UNAM, BUAP.
Montes-García, J.F., Rojas, L., Zenteno, E., Vazquez-Cruz, C. y Negrete-Abascal, E. (2020). Characterization of Actinobacillus seminis biofilm formation. Antonie van Leeuwenhoek. 113:1371-1383.
Moustacas, V. S., Silva, T. M. A., Costa, L. F., Carvalho-Júnior, C. A., Santos, R. L. y Paixão, T. A. (2014). Clinical and pathological changes in rams experimentally infected with Actinobacillus seminis and Histophilus somni. The Scientific World Journal. 24:1452-1465.
Nakano, M., Takahashi, A., Sakai, Y. y Nakaya, Y. (2007). Modulation of Pathogenicity with Norepinephrine Related to the Type III Secretion System of Vibrio parahaemolyticus. The Journal of Infectious Diseases. 195(9):1353-1360.
Nelson D. L. y Cox M. (2019). Lehninger Principios de Bioquímica. 7a. Edición. pp 349-369. Editorial Omega.
Obr, A. y Edwards D. (2012). The biology of progesterone receptor in the normal mammary gland in breast cancer. Molecular and Cellular Endocrinology. 357(1-2):4-17.
Pennell, L. M., Galligan, C. L. y Fish, E. N. (2012). Sex affects immunity. Journal of Autoimmunity. 38(3):282-291.
Pérez Márquez, V. M., Ochoa, J. L., Cruz, C. V., Alonso, P. S., Olmedo-Alvarez, G., Vaca, S., & Abascal, E. N. (2014). Isolation of Actinobacillus pleuropneumoniae from layer hens showing clinical signs of infectious coryza. Avian diseases, 58(4), 638–641.
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2023-05-01
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Ramírez-Paz-y-Puente, G. A. ., Vázquez-Cruz, C. ., Sánchez-Alonso, P. ., & Negrete-Abascal, E. . (2023). Hormonas Esteroideas Sexuales: Moléculas Moderadoras de la Infección Bacteriana. RD-ICUAP, 9(26), 33–51. https://doi.org/10.32399/icuap.rdic.2448-5829.2023.26.1080
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