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Burning of fossil fuels has brought several conflicts worldwide, impacting on the overheating of the planet. There is an alternative that replaces the use of these sources: biofuels. Biobutanol has become a focal point for the biotechnology industry due to its advantages among other biofuels. However, there are certain limitations on its production such as: raw material composition, expensive treatments and the complex metabolic pathways. On this paper we expose an overview about the actual potential of Thermoanaerobacterium thermosaccharolyticum TG57 as a microorganism with an efficient biobutanol production capability.