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Ambystoma mexicanum is an endemic species of Mexico that attracts the spotlight of the scientific community thanks to its regenerative capacities and its particular genome, which makes it an ideal animal model for research in the area of tissue therapy, another part of this Attention is due to the fact that it is in danger of extinction, which has led to the generation of strategies for its conservation. The objective of this article is to disseminate important information on the current situation of Ambystoma mexicanum, addressing its genomic characteristics, its regeneration mechanism and the proposals for its preservation.