In late 2019, the emergence of SARS-CoV-2, better known as coronavirus, was witnessed by humankind leading to a pandemic that has stopped a large number of important activities worldwide. Due to the alarming consequences of this pandemic, several scientific groups around the world have been assigned the task of designing an effective vaccine against SARS-CoV-2. Meanwhile, the results in the search for possible treatments have been utterly ineffective, so vaccination for the entire population represents a more practical option. Since this is a complicated and considerable task, this paper will describe the general picture experienced around the design of COVID-19 vaccines and will address the possible difficulties that may occur during their development and administration.